Journal article
GB Virus C (GBV-C) Infection in Hepatitis C Virus (HCV) Seropositive Women with or at Risk for HIV Infection
PloS one, Vol.9(12), pp.e114467-e114467
12/10/2014
DOI: 10.1371/journal.pone.0114467
PMCID: PMC4262414
PMID: 25493916
Abstract
GB virus C (GBV-C) may have a beneficial impact on HIV disease progression; however, the epidemiologic characteristics of this virus are not well characterized. Behavioral factors and gender may lead to differential rates of GBV-C infection; yet, studies have rarely addressed GBV-C infections in women or racial/ethnic minorities. Therefore, we evaluated GBV-C RNA prevalence and genotype distribution in a large prospective study of high-risk women in the US.
438 hepatitis C virus (HCV) seropositive women, including 306 HIV-infected and 132 HIV-uninfected women, from the HIV Epidemiologic Research Study were evaluated for GBV-C RNA. 347 (79.2%) women were GBV-C RNA negative, while 91 (20.8%) were GBV-C RNA positive. GBV-C positive women were younger than GBV-C negative women. Among 306 HIV-infected women, 70 (22.9%) women were HIV/GBV-C co-infected. Among HIV-infected women, the only significant difference between GBV-negative and GBV-positive women was age (mean 38.4 vs. 35.1 years; p<0.001). Median baseline CD4 cell counts and plasma HIV RNA levels were similar. The GBV-C genotypes were 1 (n = 31; 44.3%), 2 (n = 36; 51.4%), and 3 (n = 3; 4.3%). The distribution of GBV-C genotypes in co-infected women differed significantly by race/ethnicity. However, median CD4 cell counts and log10 HIV RNA levels did not differ by GBV-C genotype. GBV-C incidence was 2.7% over a median follow-up of 2.9 (IQR: 1.5, 4.9) years, while GBV-C clearance was 35.7% over a median follow-up of 2.44 (1.4, 3.5) years. 4 women switched genotypes.
Age, injection drug use, a history of sex for money or drugs, and number of recent male sex partners were associated with GBV-C infection among all women in this analysis. However, CD4 cell count and HIV viral load of HIV/HCV/GBV-C co-infected women were not different although race was associated with GBV-C genotype.
Details
- Title: Subtitle
- GB Virus C (GBV-C) Infection in Hepatitis C Virus (HCV) Seropositive Women with or at Risk for HIV Infection
- Creators
- Jason T Blackard - University of Cincinnati Medical CenterGang Ma - University of Cincinnati Medical CenterJeffrey A Welge - University of Cincinnati Medical CenterCaroline C King - Centers for Disease Control and PreventionLynn E Taylor - Miriam HospitalKenneth H Mayer - Fenway HealthRobert S Klein - Icahn School of Medicine at Mount SinaiDavid D Celentano - Johns Hopkins UniversityJack D Sobel - Wayne State UniversityDenise J Jamieson - Centers for Disease Control and PreventionLytt Gardner - Centers for Disease Control and Prevention
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.9(12), pp.e114467-e114467
- DOI
- 10.1371/journal.pone.0114467
- PMID
- 25493916
- PMCID
- PMC4262414
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Grant note
- P30 DK078392 / NIDDK NIH HHS R21 AI081564 / NIAID NIH HHS
- Language
- English
- Date published
- 12/10/2014
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446428502771
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