Journal article
GB Virus C Replicates in Primary T and B Lymphocytes
The Journal of infectious diseases, Vol.193(3), pp.451-454
02/01/2006
DOI: 10.1086/499435
PMID: 16388494
Abstract
GB virus C (GBV-C) infection is common in humans and may persist for decades, although most infected persons clear the virus and subsequently develop antibodies to the envelope glycoprotein. GBV-C replicates in peripheral blood mononuclear cells (PBMCs) and CD4+ T lymphocytes in vitro, and depletion of CD4+ T lymphocytes has been proposed as the reason for clearance of GBV-C among persons positive for human immunodeficiency virus. We identified GBV-C RNA in purified CD4+ and CD8+ T lymphocytes and CD19+ B lymphocytes removed ex vivo from infected donors and found that GBV-C replicated in vitro in these PBMC subsets, suggesting that GBV-C is a panlymphotropic virus
Details
- Title: Subtitle
- GB Virus C Replicates in Primary T and B Lymphocytes
- Creators
- Sarah L George - Research Service and Department of Internal Medicine, Saint Louis University Hospital and St. Louis Veterans Affairs Medical Center, St. Louis, MissouriDino Varmaz - Research Service and Department of Internal Medicine, Saint Louis University Hospital and St. Louis Veterans Affairs Medical Center, St. Louis, MissouriJack T Stapleton - Research Service and Department of Internal Medicine, Iowa City Veterans Affairs Medical Center and the University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.193(3), pp.451-454
- DOI
- 10.1086/499435
- PMID
- 16388494
- NLM abbreviation
- J Infect Dis
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Publisher
- The University of Chicago Press
- Language
- English
- Date published
- 02/01/2006
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094638102771
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