Journal article
GB Virus C Viremia Is Associated With Higher Levels of Double-Negative T Cells and Lower T-Cell Activation in HIV-Infected Individuals Receiving Antiretroviral Therapy
The Journal of infectious diseases, Vol.206(9), pp.1469-1472
11/01/2012
DOI: 10.1093/infdis/jis515
PMCID: PMC3466998
PMID: 22927453
Abstract
Double-negative T cells (DNTCs; ie, CD3
+
CD4
–
CD8
–
T cells) play a role in limiting chronic immune activation. GB virus C (GBV-C) infection is associated with reduced T-cell activation in human immunodeficiency virus (HIV)–infected individuals. T-cell activation and DNTCs were measured in HIV-infected subjects with a nondetectable HIV load. GBV-C–viremic subjects had significantly reduced CD4
+
and CD8
+
T-cell activation (
P
= .003 and .034, respectively) and significantly increased DNTCs (
P
= .038), compared with nonviremic subjects. GBV-C load correlated with DNTC percentage (
P
= .004). Thus, GBV-C infection is associated with an increase in DNTCs, which may contribute to reduced immune activation during HIV infection.
Details
- Title: Subtitle
- GB Virus C Viremia Is Associated With Higher Levels of Double-Negative T Cells and Lower T-Cell Activation in HIV-Infected Individuals Receiving Antiretroviral Therapy
- Creators
- Nirjal BhattaraiRobert T RydzeErnest T ChiveroJack T Stapleton - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.206(9), pp.1469-1472
- Publisher
- Oxford University Press
- DOI
- 10.1093/infdis/jis515
- PMID
- 22927453
- PMCID
- PMC3466998
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 11/01/2012
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094553402771
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