Journal article
GB Virus Type C Infection Polarizes T-Cell Cytokine Gene Expression Toward a Th1 Cytokine Profile via NS5A Protein Expression
The Journal of infectious diseases, Vol.206(1), pp.69-72
07/01/2012
DOI: 10.1093/infdis/jis312
PMCID: PMC3415935
PMID: 22535999
Abstract
Human immunodeficiency virus (HIV) disease progression is associated with a helper T cell 1 (Th1) to helper T cell 2 (Th2) cytokine profile switch. Persistent GB virus type C (GBV-C) infection is associated with survival and a serum Th1 cytokine profile in HIV-infected individuals. We found that GBV-C infection increased gene expression of Th1 cytokines and decreased Th2 cytokine expression in peripheral blood mononuclear cells. Furthermore, expression of GBV-C NS5A protein in a CD4
+
cell line resulted in upregulation of Th1 cytokines (tumor necrosis factor α) and downregulation of Th2 cytokines (interleukin 4, interleukin 5, interleukin 10, interleukin 13). GBV-C–induced modulation in T-cell cytokines may contribute to the beneficial effect of GBV-C in HIV-infected individuals.
Details
- Title: Subtitle
- GB Virus Type C Infection Polarizes T-Cell Cytokine Gene Expression Toward a Th1 Cytokine Profile via NS5A Protein Expression
- Creators
- Robert T Rydze - Doris Duke Scholars Program, Iowa City, IowaJinhua XiangJames H McLindenJack T Stapleton - Doris Duke Scholars Program, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.206(1), pp.69-72
- Publisher
- Oxford University Press
- DOI
- 10.1093/infdis/jis312
- PMID
- 22535999
- PMCID
- PMC3415935
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 07/01/2012
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094209202771
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