Journal article
GB virus C infection among young, HIV-negative injection drug users with and without hepatitis C virus infection
Journal of viral hepatitis, Vol.18(4), pp.e153-e159
04/2011
DOI: 10.1111/j.1365-2893.2010.01350.x
PMCID: PMC3543827
PMID: 20738773
Abstract
Our study examined the association between GB virus C (GBV-C) and (i) hepatitis C virus (HCV) infection status, (ii) biomedical indicators of liver disease (alanine and aspartate aminotransferases) and (iii) HCV RNA level among young injection drug users (IDUs) recruited using street outreach and respondent-driven methods. Cross-sectional and longitudinal analyses were completed. GBV-C (active or resolved) infection was significantly (
P
< 0.05) more prevalent among HCV antibody-positive (anti-HCV+) (65.1%) than antibody-negative (anti-HCV–) (32.3%) (OR = 3.9, 95% CI: 2.3–6.9) IDUs. The prevalence of resolved GBV-C infection was highest among those with chronic HCV infection (41.9%), followed by those with resolved HCV infection (34.4%) and significantly lower (
P
< 0.05) among anti-HCV participants (16.9%). Although not statistically significant (
P
= 0.13), a similar pattern was observed for active GBV-C infection. No association between GBV-C infection status and biomedical indicators of liver disease or HCV RNA level over time was observed. In conclusion, GBV-C infection prevalence was higher among anti-HCV+ compared to anti-HCV– young IDUs, similar to prior studies among older populations. In particular, chronically HCV-infected young IDUs had an increased rate of GBV-C clearance.
Details
- Title: Subtitle
- GB virus C infection among young, HIV-negative injection drug users with and without hepatitis C virus infection
- Creators
- B Boodram - Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL, USAR. C Hershow - Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL, USAD Klinzman - Department of Internal Medicine, Division of Infectious Diseases, Iowa City Veterans Administration and the University of Iowa, Iowa City, IA, USAJ. T Stapleton - Department of Internal Medicine, Division of Infectious Diseases, Iowa City Veterans Administration and the University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of viral hepatitis, Vol.18(4), pp.e153-e159
- DOI
- 10.1111/j.1365-2893.2010.01350.x
- PMID
- 20738773
- PMCID
- PMC3543827
- NLM abbreviation
- J Viral Hepat
- ISSN
- 1352-0504
- eISSN
- 1365-2893
- Grant note
- R01 AI058740 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094566602771
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