GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals

Jack T Stapleton; Jeffrey A Martinson; Donna Klinzman; Jinhua Xiang; Seema N Desai; Alan Landay

doi:10.1097/QAD.0b013e328363089f

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GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals

Journal article

Open access

Peer reviewed

GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals

Jack T Stapleton, Jeffrey A Martinson, Donna Klinzman, Jinhua Xiang, Seema N Desai and Alan Landay

AIDS (London), Vol.27(11), pp.1829-1832

07/17/2013

DOI: 10.1097/QAD.0b013e328363089f

PMCID: PMC4539006

PMID: 23807277

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Abstract

GB virus C (GBV-C), a pan-lymphotropic flavivirus capable of persistent infection, is associated with prolonged survival and reduced T-cell activation in HIV-infected patients. GBV-C was associated with reduced CD56brt/CD16- natural killer cell and monocyte activation, and a trend toward reduced B-cell activation by measuring cell surface activation markers or HIV entry coreceptors. The GBV-C association was independent of HIV viral load. Thus, GBV-C may influence non-T-cell immune activation in individuals with HIV infection.

Flaviviridae Infections - pathology

GB virus C - immunology

CD56 Antigen - analysis

GPI-Linked Proteins - analysis

Humans

Immune Tolerance

Monocytes - immunology

Flaviviridae Infections - virology

Hepatitis, Viral, Human - pathology

B-Lymphocytes - immunology

Receptors, IgG - analysis

Hepatitis, Viral, Human - virology

HIV Infections - complications

Killer Cells, Natural - immunology

Flaviviridae Infections - diagnosis

Hepatitis, Viral, Human - diagnosis

Details

Title: Subtitle: GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals
Creators: Jack T Stapleton - Research and Medical Services, Iowa City VA Medical Center, Iowa City, IA 52242, USA. jack-stapleton@uiowa.edu
Jeffrey A Martinson
Donna Klinzman
Jinhua Xiang
Seema N Desai
Alan Landay
Resource Type: Journal article
Publication Details: AIDS (London), Vol.27(11), pp.1829-1832
DOI: 10.1097/QAD.0b013e328363089f
PMID: 23807277
PMCID: PMC4539006
NLM abbreviation: AIDS
ISSN: 0269-9370
eISSN: 1473-5571
Grant note: R01 AI058740 / NIAID NIH HHS T32 AI007343 / NIAID NIH HHS I01 BX000207 / BLRD VA I01 BX001241 / BLRD VA I01 CX000821 / CSRD VA
Language: English
Date published: 07/17/2013
Academic Unit: Microbiology and Immunology; Infectious Diseases; Internal Medicine
Record Identifier: 9984094548702771

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