Journal article
GB virus C infection in children with perinatal human immunodeficiency virus infection
The Pediatric infectious disease journal, Vol.24(5), pp.417-422
2005
DOI: 10.1097/01.inf.0000160943.17750.94
PMID: 15876940
Abstract
Background:
GB virus C (GBV-C) infection occurs in 20–40% of human immunodeficiency virus (HIV)-infected adults, and coinfection is associated with improved HIV disease outcome.
Methods:
To determine the prevalence of GBV-C infection in children who were perinatally infected with HIV, we conducted a cross-sectional prevalence survey in a cohort of perinatally infected HIV-positive children selected from a large, multicenter observational protocol. A blood specimen was obtained and tested for GBV-C viremia with the use of a qualitative GBV-C RNA assay and screened for past GBV-C infection with enzyme-linked immunosorbent assay to detect antibodies to the GBV-C envelope protein E2 (E2 Ab).
Results:
The 354 children who participated in the substudy were relatively healthy, with a median CD4 of 784 cells/mm3 and median HIV-1 viral load of 1055 copies/mL. The prevalence of GBV-C viremia was 20 of 353 or 5.7% (95% confidence interval, 3.5–8.6%), and the prevalence of E2 Ab was 12 of 354 or 3.4% (95% confidence interval, 1.8–5.8%). GBV-C viremic patients were older than patients without past GBV-C infection (median age, 12.8 years versus 10.7 years). Median CD4+ lymphocyte counts were highest in subjects without GBV-C infection and lowest in those with E2 Ab.
Conclusions:
GBV-C prevalence rates are lower in children with perinatal HIV infection than those reported for HIV-infected adults. With the exception of evidence that GBV-C viremic children had lower rates of Centers for Disease Control and Prevention HIV disease category C disease before GBV-C testing, we did not find evidence of improved HIV disease outcome in coinfected patients, but the number of HIV/GBV-C-coinfected children was small.
Details
- Title: Subtitle
- GB virus C infection in children with perinatal human immunodeficiency virus infection
- Creators
- Susan SCHUVAL - Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, NY, United StatesJane C LINDSEY - Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA, United StatesBarbara NOWAK - Frontier Science and Technology Research Foundation, Amherst, NY, United StatesGregory CIUPAK - Frontier Science and Technology Research Foundation, Amherst, NY, United StatesNancy WEBB - Frontier Science and Technology Research Foundation, Amherst, NY, United StatesMichelle EAGLE - University of Florida Health Science Center, Jacksonville, FL, United StatesDorothy SMITH - University of Massachusetts Memorial Health Care, Worcester, MA, United StatesRoslyn HENNESSEY - Westat, Inc, Rockville, MD, United StatesMelissa GOODMAN-KERKAU - University of North Carolina Retrovirology Core Laboratory, Chapel Hill, NC, United StatesDonna KLINZMAN - University of Iowa, United StatesGeorg HESS - Roche Diagnostics, Mannheim, GermanyJack T STAPLETON - University of Iowa, United StatesDietmar ZDUNEK - Troche Diagnostics, Penzburg, GermanyMyron J LEVIN - University of Colorado Health Sciences Center, Denver, CO, United StatesRussell B VAN DYKE - Tulane University Health Sciences Center, New Orleans, LA, United StatesPaul PALUMBO - University of Medicine and Dentistry of New Jersey, Newark, NJ, United StatesLynne M MOFENSON - National Institute of Child Health and Human Development, Rockville, MD, United StatesJames M OLESKE - University of Medicine and Dentistry of New Jersey, Newark, NJ, United StatesJoseph CERVIA - Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, NY, United StatesAndrea KOVACS - University of Southern California Medical Center, Los Angeles, CA, United StatesWayne N DANKNER - Duke University Medical Center, Durham, NC, United StatesPediatric AIDS Clinical Trials Group Protocol 1028S Team
- Resource Type
- Journal article
- Publication Details
- The Pediatric infectious disease journal, Vol.24(5), pp.417-422
- Publisher
- Lippincott
- DOI
- 10.1097/01.inf.0000160943.17750.94
- PMID
- 15876940
- ISSN
- 0891-3668
- eISSN
- 1532-0987
- Language
- English
- Date published
- 2005
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094666702771
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