Journal article
GB virus C: the good boy virus?
Trends in microbiology (Regular ed.), Vol.20(3), pp.124-130
03/2012
DOI: 10.1016/j.tim.2012.01.004
PMCID: PMC3477489
PMID: 22325031
Abstract
GB virus C (GBV-C) is a lymphotropic human virus discovered in 1995 that is related to hepatitis C virus (HCV). GBV-C infection has not been convincingly associated with any disease; however, several studies found an association between persistent GBV-C infection and improved survival in HIV-positive individuals. GBV-C infection modestly alters T cell homeostasis in vivo through various mechanisms, including modulation of chemokine and cytokine release and receptor expression, and by diminution of T cell activation, proliferation and apoptosis, all of which may contribute to improved HIV clinical outcomes. In vitro studies confirm these clinical observations and demonstrate an anti-HIV replication effect of GBV-C. This review summarizes existing data on potential mechanisms by which GBV-C interferes with HIV, and the research needed to capitalize on this epidemiological observation.
Details
- Title: Subtitle
- GB virus C: the good boy virus?
- Creators
- Nirjal Bhattarai - Interdisciplinary Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242, USAJack T Stapleton - Interdisciplinary Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Trends in microbiology (Regular ed.), Vol.20(3), pp.124-130
- DOI
- 10.1016/j.tim.2012.01.004
- PMID
- 22325031
- PMCID
- PMC3477489
- NLM abbreviation
- Trends Microbiol
- ISSN
- 0966-842X
- eISSN
- 1878-4380
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 03/2012
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094373402771
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