Journal article
GB virus type C interactions with HIV: the role of envelope glycoproteins
Journal of viral hepatitis, Vol.16(11), pp.757-768
11/2009
DOI: 10.1111/j.1365-2893.2009.01194.x
PMCID: PMC3543829
PMID: 19758271
Abstract
GB virus C/hepatitis G virus (GBV-C/HGV) is the most closely related human virus to hepatitis C virus (HCV). GBV-C is lymphotropic and not associated with any known disease, although it is associated with improved survival in HIV-infected individuals. In peripheral blood mononuclear cells, GBV-C induces the release of soluble ligands for HIV entry receptors (RANTES, MIP-1a, MIP-1b and SDF-1), suggesting that GBV-C may interact with lymphocytes to induce a chemokine and/or cytokine milieu that is inhibitory to HIV infection. Expression of GBV-C envelope glycoprotein E2 in CD4+ T cells or addition of recombinant E2 to CD4 cells recapitulates the HIV inhibition seen with GBV-C infection. Like HCV E2, GBV-C E2 is predicted to be post-translationally processed in the endoplasmic reticulum and is involved with cell binding. The C-termini of GBV-C E1 and E2 proteins contain predicted transmembrane domains sharing features with HCV TM domains. To date, cellular receptor(s) for GBV-C E2 have not been identified. GBV-C E2-mediated HIV inhibition is dose-dependent and HIV replication is blocked at the binding and/or entry step. In addition, a putative GBV-C E2 fusion peptide interferes with HIV gp41 peptide oligomerization required for HIV-1 fusion, further suggesting that GBV-C E2 may inhibit HIV entry. Additional work is needed to identify the GBV-C E2 cellular receptor, characterize GBV-C E2 domains responsible for HIV inhibition, and to examine GBV-C E2-mediated fusion in the context of the entire envelope protein or viral-particles. Understanding the mechanisms of action may identify novel approaches to HIV therapy.
Details
- Title: Subtitle
- GB virus type C interactions with HIV: the role of envelope glycoproteins
- Creators
- Emma L Mohr - Department of Internal Medicine and the Interdisciplinary Program on Molecular and Cellular Biology, The University of IowaJack T Stapleton - Department of Internal Medicine and the Interdisciplinary Program on Molecular and Cellular Biology, The University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of viral hepatitis, Vol.16(11), pp.757-768
- DOI
- 10.1111/j.1365-2893.2009.01194.x
- PMID
- 19758271
- PMCID
- PMC3543829
- NLM abbreviation
- J Viral Hepat
- ISSN
- 1352-0504
- eISSN
- 1365-2893
- Grant note
- R01 AI058740 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
- Language
- English
- Date published
- 11/2009
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094213202771
Metrics
17 Record Views