Journal article
GB virus type C/hepatitis G virus: a non-pathogenic flavivirus associated with prolonged survival in HIV-infected individuals
Microbes and Infection, Vol.5(13), pp.1255-1261
2003
DOI: 10.1016/j.micinf.2003.08.006
PMID: 14623022
Abstract
GB virus C (GBV-C) is a common virus that does not appear to cause disease. GBV-C persists in up to 50% of exposed individuals, and virus replication appears to be in lymphocytes including CD4+ T cells. GBV-C infection is common among HIV-positive people, and several studies have found that HIV-positive individuals co-infected with GBV-C survive for statistically significantly longer periods of time than people without GBV-C. In vitro studies suggest that GBV-C inhibits HIV replication and alters cytokine, chemokine and chemokine receptor expression. Thus, GBV-C may be a major factor influencing the natural history of HIV disease.
Details
- Title: Subtitle
- GB virus type C/hepatitis G virus: a non-pathogenic flavivirus associated with prolonged survival in HIV-infected individuals
- Creators
- Philip M Polgreen - Departments of Internal Medicine and Research, Iowa City VA Medical Center, Internal Medicine SW34-P, GH, University of Iowa, UIHC, 200 Hawkins Drive, Iowa City, IA 52242, USAJinhua Xiang - Departments of Internal Medicine and Research, Iowa City VA Medical Center, Internal Medicine SW34-P, GH, University of Iowa, UIHC, 200 Hawkins Drive, Iowa City, IA 52242, USAQing Chang - Departments of Internal Medicine and Research, Iowa City VA Medical Center, Internal Medicine SW34-P, GH, University of Iowa, UIHC, 200 Hawkins Drive, Iowa City, IA 52242, USAJack T Stapleton - Departments of Internal Medicine and Research, Iowa City VA Medical Center, Internal Medicine SW34-P, GH, University of Iowa, UIHC, 200 Hawkins Drive, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Microbes and Infection, Vol.5(13), pp.1255-1261
- DOI
- 10.1016/j.micinf.2003.08.006
- PMID
- 14623022
- NLM abbreviation
- Microbes Infect
- ISSN
- 1286-4579
- eISSN
- 1769-714X
- Publisher
- Elsevier SAS
- Language
- English
- Date published
- 2003
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984094632102771
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