GBV-C infection and risk of NHL among U.S. adults

Cindy M Chang; Jack T Stapleton; Donna Klinzman; James H McLinden; Mark P Purdue; Hormuzd A Katki; Eric A Engels

doi:10.1158/0008-5472.CAN-14-0209

Back

GBV-C infection and risk of NHL among U.S. adults

Journal article

Open access

Peer reviewed

GBV-C infection and risk of NHL among U.S. adults

Cindy M Chang, Jack T Stapleton, Donna Klinzman, James H McLinden, Mark P Purdue, Hormuzd A Katki and Eric A Engels

Cancer research (Chicago, Ill.), Vol.74(19), pp.5553-5560

10/01/2014

DOI: 10.1158/0008-5472.CAN-14-0209

PMCID: PMC4184918

PMID: 25115299

Files and links (1)

url

https://doi.org/10.1158/0008-5472.CAN-14-0209View

Published (Version of record) Open Access

Abstract

Some retrospective studies suggest an association between infection with GB virus-C (GBV-C) and non-Hodgkin lymphoma (NHL). We evaluated this association prospectively in a nested case-control study within the U.S. Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Cases (N = 658) and controls (N = 1,316) were individually matched by age, sex, race/ethnicity, timing of study entry, and sample selection. Prediagnostic PLCO serum samples were tested for GBV-C RNA (as a measure of active infection) and E2 antibody (active or resolved infection). Logistic regression was used to estimate odds ratios (OR) for the association between GBV-C and NHL overall and NHL subtypes. Twelve cases (1.8%) and seven controls (0.5%) were GBV-C RNA-positive. GBV-C RNA positivity was associated with NHL overall [OR, 3.43; 95% confidence interval (CI), 1.35-8.71] and, based on small numbers, diffuse large B-cell lymphoma (OR, 5.31; 95% CI, 1.54-18.36). The association with NHL persisted when the interval between testing and selection was greater than 4 years (OR, 6.00; 95% CI, 1.21-29.73). In contrast, E2 antibody positivity was not associated with NHL risk (OR, 1.08; 95% CI, 0.74-1.58). Our study demonstrates that GBV-C infection precedes development of NHL. GBV-C infection may play an etiologic role in a small proportion of NHL cases, perhaps by causing chronic immune stimulation or impaired immunosurveillance.

United States - epidemiology

Flaviviridae Infections - complications

Lymphoma, Non-Hodgkin - virology

GB virus C - isolation & purification

Humans

Middle Aged

Risk Factors

Male

DNA Primers

Lymphoma, Non-Hodgkin - epidemiology

Reverse Transcriptase Polymerase Chain Reaction

Case-Control Studies

Base Sequence

Female

Hepatitis, Viral, Human - complications

Aged

GB virus C - genetics

Real-Time Polymerase Chain Reaction

Details

Title: Subtitle: GBV-C infection and risk of NHL among U.S. adults
Creators: Cindy M Chang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland. cindy.chang@fda.hhs.gov
Jack T Stapleton - Department of Internal Medicine, Iowa City Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa
Donna Klinzman - Department of Internal Medicine, Iowa City Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa
James H McLinden - Department of Internal Medicine, Iowa City Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa
Mark P Purdue - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland
Hormuzd A Katki - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland
Eric A Engels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland
Resource Type: Journal article
Publication Details: Cancer research (Chicago, Ill.), Vol.74(19), pp.5553-5560
DOI: 10.1158/0008-5472.CAN-14-0209
PMID: 25115299
PMCID: PMC4184918
NLM abbreviation: Cancer Res
ISSN: 0008-5472
eISSN: 1538-7445
Grant note: Z01 CP010150-08 / Intramural NIH HHS I01 CX000821 / CSRD VA I01 BX000207 / BLRD VA
Language: English
Date published: 10/01/2014
Academic Unit: Microbiology and Immunology; Infectious Diseases; Internal Medicine
Record Identifier: 9984094387402771

Metrics

15 Record Views

45 Times Cited - Web of Science