Journal article
GENOME-WIDE ASSOCIATION STUDY OF BIPOLAR DISORDER IN EUROPEAN AMERICAN AND AFRICAN AMERICAN INDIVIDUALS
Molecular psychiatry, Vol.14(8), pp.755-763
08/2009
DOI: 10.1038/mp.2009.43
PMCID: PMC3035981
PMID: 19488044
Abstract
To identify Bipolar Disorder (BD) genetic susceptibility factors, we conducted two genome-wide association (GWA) studies: one involving a sample of individuals of European ancestry (EA; n = 1,001 cases; n = 1,033 controls) and one involving a sample of individuals of African ancestry (AA; n = 345 cases; n = 670 controls). For the EA sample, SNPs with strongest statistical evidence for association included rs5907577 in an intergenic region at Xq27.1 (p = 1.6 × 10
-6
) and rs10193871 in
NAP5
at 2q21.2 (p = 9.8 × 10
-6
). For the AA sample, SNPs with strongest statistical evidence for association included rs2111504 in
DPY19L3
at 19q13.11 (p = 1.5 × 10
-6
) and rs2769605 in
NTRK2
at 9q21.33 (p = 4.5 × 10
-5
). We also investigated whether we could provide support for three regions previously associated with BD, and we show that the
ANK3
region replicates in our sample, along with some support for
C15Orf53
; other evidence implicates BD candidate genes such as
SLITRK2
. We also tested the hypothesis that BD susceptibility variants exhibit genetic background-dependent effects; SNPs with the strongest statistical evidence for this included rs11208285 in
ROR1
at 1p31.3 (p = 1.4 × 10
-6
), rs4657247 in
RGS5
at 1q23.3 (p = 4.1 × 10
-6
), and rs7078071 in
BTBD16
at 10q26.13 (p = 4.5 × 10
-6
). This study is the first to conduct GWA of BD in individuals of AA and suggests that genetic variations that contribute to BD may vary as a function of ancestry.
Details
- Title: Subtitle
- GENOME-WIDE ASSOCIATION STUDY OF BIPOLAR DISORDER IN EUROPEAN AMERICAN AND AFRICAN AMERICAN INDIVIDUALS
- Creators
- Erin N Smith - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USACinnamon S Bloss - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAJudith A Badner - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAThomas Barrett - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAPamela L Belmonte - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAWade Berrettini - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAWilliam Byerley - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAWilliam Coryell - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USADavid Craig - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAHoward J Edenberg - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAEleazar Eskin - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USATatiana Foroud - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAElliot Gershon - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USATiffany A Greenwood - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAMaria Hipolito - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USADaniel L Koller - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAWilliam B Lawson - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAChunyu Liu - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAFalk Lohoff - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAMelvin G McInnis - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAFrancis J McMahon - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USADaniel B Mirel - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USACaroline Nievergelt - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAJohn Nurnberger - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAEvaristus A Nwulia - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAJustin Paschall - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAJames B Potash - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAJohn Rice - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAThomas G Schulze - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAWilliam Scheftner - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USACorrie Panganiban - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USANoah Zaitlen - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAPeter P Zandi - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USASebastian Zöllner - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USANicholas J Schork - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USAJohn R Kelsoe - Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, 92151, USA
- Resource Type
- Journal article
- Publication Details
- Molecular psychiatry, Vol.14(8), pp.755-763
- DOI
- 10.1038/mp.2009.43
- PMID
- 19488044
- PMCID
- PMC3035981
- NLM abbreviation
- Mol Psychiatry
- ISSN
- 1359-4184
- eISSN
- 1476-5578
- Language
- English
- Date published
- 08/2009
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003907802771
Metrics
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