Journal article
GMF-Knockout mice are unable to induce brain-derived neurotrophic factor after exercise
Neurochemical research, Vol.31(4), pp.579-584
04/01/2006
DOI: 10.1007/s11064-006-9049-3
Abstract
We earlier reported that overexpression of glia maturation factor (GMF) in cultured astrocytes enhances the production of brain-derived neurotrophic factor (BDNF). The current study was conducted to find out whether BDNF production is impaired in animals devoid of GMF. To this end GMF-knockout (KO) mice were subjected to exercise and the neurotrophin mRNAs were determined by real-time RT-PCR. Compared to wild-type (WT) mice, there is a decrease in exercise-induced BDNF in the KO mice. The observation was correlated with the finding that, in WT mice, exercise increases GMF expression. The results are consistent with the hypothesis that GMF is necessary for exercise-induction of BDNF, and that GMF may promote neuroprotection through BDNF production.
Details
- Title: Subtitle
- GMF-Knockout mice are unable to induce brain-derived neurotrophic factor after exercise
- Creators
- Asgar ZaheerJoel T. HaasCarlos ReyesSatya N. MathurBaoli Yang - University of IowaRamon Lim
- Resource Type
- Journal article
- Publication Details
- Neurochemical research, Vol.31(4), pp.579-584
- DOI
- 10.1007/s11064-006-9049-3
- ISSN
- 0364-3190
- Language
- English
- Date published
- 04/01/2006
- Academic Unit
- BioVentures Center; Neurology; Obstetrics and Gynecology
- Record Identifier
- 9983557424702771
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