GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins

Anne P Beigneux; Brandon S J Davies; André Bensadoun; Loren G Fong; Stephen G Young

doi:10.1194/jlr.R800030-JLR200

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GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins

Journal article

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GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins

Anne P Beigneux, Brandon S J Davies, André Bensadoun, Loren G Fong and Stephen G Young

Journal of lipid research, Vol.50 Suppl(Supplement), pp.S57-S62

04/2009

DOI: 10.1194/jlr.R800030-JLR200

PMCID: PMC2674691

PMID: 18854402

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Abstract

GPIHBP1, a small glycosylphosphatidylinositol-anchored glycoprotein, is required for the lipolytic processing of triglyceride-rich lipoproteins. GPIHBP1 knockout mice exhibit chylomicronemia, even on a low-fat diet, with plasma triglyceride levels of 3,500-5,000 mg/dl. GPIHBP1 is expressed highly in heart, adipose tissue, and skeletal muscle, the same tissues that express high levels of lipoprotein lipase (LPL). In each of these tissues, GPIHBP1 is located in capillary endothelial cells. Chinese hamster ovary (CHO) cells transfected with a GPIHBP1 expression vector bind LPL and chylomicrons avidly. The expression of GPIHBP1 in mice is modulated by fasting and refeeding and is also regulated by peroxisome proliferator-activated receptor (PPAR)gamma agonists. Here, we review recent progress in understanding GPIHBP1 and discuss its role in lipolysis.

Carrier Proteins - genetics

Animals

Carrier Proteins - metabolism

Hyperlipidemias - metabolism

Membrane Glycoproteins - metabolism

Humans

Lipoproteins - metabolism

Carrier Proteins - chemistry

Lipid Metabolism

PPAR gamma - metabolism

Carrier Proteins - classification

Triglycerides - metabolism

Details

Title: Subtitle: GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins
Creators: Anne P Beigneux - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. abeigneux@mednet.ucla.edu
Brandon S J Davies
André Bensadoun
Loren G Fong
Stephen G Young
Resource Type: Journal article
Publication Details: Journal of lipid research, Vol.50 Suppl(Supplement), pp.S57-S62
DOI: 10.1194/jlr.R800030-JLR200
PMID: 18854402
PMCID: PMC2674691
NLM abbreviation: J Lipid Res
ISSN: 0022-2275
eISSN: 1539-7262
Publisher: United States
Grant note: P01 HL090553-02S2 / NHLBI NIH HHS R01 HL087228-03 / NHLBI NIH HHS P01 HL090553-02 / NHLBI NIH HHS P01 HL090553-01A10001 / NHLBI NIH HHS P01 HL090553 / NHLBI NIH HHS R01 HL087228-04 / NHLBI NIH HHS P01 HL090553-01A19002 / NHLBI NIH HHS R01 HL087228-01 / NHLBI NIH HHS P01 HL090553-02S1 / NHLBI NIH HHS 5R01HL087228-02 / NHLBI NIH HHS R01 HL087228 / NHLBI NIH HHS P01 HL090553-01A1 / NHLBI NIH HHS R01 HL087228-02 / NHLBI NIH HHS 5P01HL090553-02 / NHLBI NIH HHS P01 HL090553-020001 / NHLBI NIH HHS P01 HL090553-029002 / NHLBI NIH HHS
Language: English
Date published: 04/2009
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
Record Identifier: 9984025394402771

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