GPIHBP1, an endothelial cell transporter for lipoprotein lipase

Stephen G Young; Brandon S. J Davies; Constance V Voss; Peter Gin; Michael M Weinstein; Peter Tontonoz; Karen Reue; André Bensadoun; Loren G Fong; Anne P Beigneux

doi:10.1194/jlr.R018689

Back

GPIHBP1, an endothelial cell transporter for lipoprotein lipase

Journal article

Open access

Peer reviewed

GPIHBP1, an endothelial cell transporter for lipoprotein lipase

Stephen G Young, Brandon S. J Davies, Constance V Voss, Peter Gin, Michael M Weinstein, Peter Tontonoz, Karen Reue, André Bensadoun, Loren G Fong and Anne P Beigneux

Journal of lipid research, Vol.52(11), pp.1869-1884

11/2011

DOI: 10.1194/jlr.R018689

PMCID: PMC3196223

PMID: 21844202

Files and links (1)

url

https://doi.org/10.1194/jlr.R018689View

Published (Version of record) Open Access

Abstract

Interest in lipolysis and the metabolism of triglyceride-rich lipoproteins was recently reignited by the discovery of severe hypertriglyceridemia (chylomicronemia) in glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1)-deficient mice. GPIHBP1 is expressed exclusively in capillary endothelial cells and binds lipoprotein lipase (LPL) avidly. These findings prompted speculation that GPIHBP1 serves as a binding site for LPL in the capillary lumen, creating “a platform for lipolysis.” More recent studies have identified a second and more intriguing role for GPIHBP1—picking up LPL in the subendothelial spaces and transporting it across endothelial cells to the capillary lumen. Here, we review the studies that revealed that GPIHBP1 is the LPL transporter and discuss which amino acid sequences are required for GPIHBP1–LPL interactions. We also discuss the human genetics of LPL transport, focusing on cases of chylomicronemia caused by GPIHBP1 mutations that abolish GPIHBP1’s ability to bind LPL, and LPL mutations that prevent LPL binding to GPIHBP1.

hypertriglyceridemia

Thematic Review

endothelial cells

lymphocyte antigen 6 proteins

chylomicrons

chylomicronemia

Details

Title: Subtitle: GPIHBP1, an endothelial cell transporter for lipoprotein lipase
Creators: Stephen G Young - Departments of Medicine
Brandon S. J Davies - Departments of Medicine
Constance V Voss - Departments of Medicine
Peter Gin - Departments of Medicine
Michael M Weinstein - Human Genetics, David Geffen School of Medicine
Peter Tontonoz - Department of Pathology and Laboratory Medicine
Karen Reue - Human Genetics, David Geffen School of Medicine
André Bensadoun - Division of Nutritional Science
Loren G Fong - Departments of Medicine
Anne P Beigneux - Departments of Medicine
Resource Type: Journal article
Publication Details: Journal of lipid research, Vol.52(11), pp.1869-1884
DOI: 10.1194/jlr.R018689
PMID: 21844202
PMCID: PMC3196223
NLM abbreviation: J Lipid Res
ISSN: 0022-2275
eISSN: 1539-7262
Publisher: The American Society for Biochemistry and Molecular Biology
Language: English
Date published: 11/2011
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
Record Identifier: 9984024410602771

Metrics

19 Record Views

88 Times Cited - Web of Science