GPIHBP1 and lipolysis: an update

Anne P Beigneux; Michael M Weinstein; Brandon S.J Davies; Peter Gin; André Bensadoun; Loren G Fong; Stephen G Young

doi:10.1097/MOL.0b013e32832ac026

Back

Journal article

Peer reviewed

GPIHBP1 and lipolysis: an update

Anne P Beigneux, Michael M Weinstein, Brandon S.J Davies, Peter Gin, André Bensadoun, Loren G Fong and Stephen G Young

Current opinion in lipidology, Vol.20(3), pp.211-216

06/2009

DOI: 10.1097/MOL.0b013e32832ac026

PMCID: PMC2810420

PMID: 19369870

Files and links (1)

url

http://doi.org/10.1097/MOL.0b013e32832ac026View

Open Access

Abstract

Purpose of review: This review will provide an update on the structure of GPIHBP1, a 28-kDa glycosylphosphatidylinositol-anchored glycoprotein, and its role in the lipolytic processing of triglyceride-rich lipoproteins. Recent findings: Gpihbp1 knockout mice on a chow diet have milky plasma and plasma triglyceride levels of more than 3000 mg/dl. GPIHBP1 is located on the luminal surface of endothelial cells in tissues where lipolysis occurs: heart, skeletal muscle, and adipose tissue. The pattern of lipoprotein lipase (LPL) release into the plasma after an intravenous injection of heparin is abnormal in Gpihbp1-deficient mice, suggesting that GPIHBP1 plays a direct role in binding LPL within the tissues of mice. Transfection of CHO cells with a GPIHBP1 expression vector confers on cells the ability to bind both LPL and chylomicrons. Two regions of GPIHBP1 are required for the binding of LPL - an amino-terminal acidic domain and the cysteine-rich Ly6 domain. GPIHBP1 expression in mice changes with fasting and refeeding and is regulated in part by peroxisome proliferator-activated receptor-gamma. Summary: GPIHBP1, an endothelial cell-surface glycoprotein, binds LPL and is required for the lipolytic processing of triglyceride-rich lipoproteins.

chylomicrons

endothelial

lipoprotein lipase

PPARγ

Details

Title: Subtitle: GPIHBP1 and lipolysis: an update
Creators: Anne P Beigneux - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California
Michael M Weinstein - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California
Brandon S.J Davies - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California
Peter Gin - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California
André Bensadoun - Division of Nutritional Science, Cornell University, Ithaca, New York, USA
Loren G Fong - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California
Stephen G Young - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California
Resource Type: Journal article
Publication Details: Current opinion in lipidology, Vol.20(3), pp.211-216
DOI: 10.1097/MOL.0b013e32832ac026
PMID: 19369870
PMCID: PMC2810420
NLM abbreviation: Curr Opin Lipidol
ISSN: 0957-9672
eISSN: 1473-6535
Language: English
Date published: 06/2009
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
Record Identifier: 9984024411102771

Metrics

18 Record Views

31 Times Cited - Web of Science