Journal article
GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release
Trends in endocrinology and metabolism, Vol.16(8), pp.362-367
10/2005
DOI: 10.1016/j.tem.2005.08.005
PMID: 16125968
Abstract
Heterotrimeric G proteins and seven-transmembrane-spanning (7TM) receptors are implicated in rapid estrogen signaling. The orphan 7TM receptor GPR30 is linked to estrogen-mediated activation of adenylyl cyclase, release of epidermal growth factor (EGF)-related ligands, and specific estrogen binding. GPR30 acts independently of estrogen receptors, ERalpha and ERbeta, and probably functions as a heptahelical ER. 7TM receptors elicit signals that stimulate second messengers, and convey intracellular signals via EGF receptors. Identification of GPR30 as a Gs-coupled 7TM receptor that triggers release of heparin-binding EGF establishes its role in cell signaling cascades initiated by estrogens, and explains their capacity to activate second messengers and promote EGF-like effects. Thus, estrogen can signal by the same mechanism as various other hormones, through a specific 7TM receptor.
Details
- Title: Subtitle
- GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release
- Creators
- Edward J Filardo - Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA. edward_filardo@brown.eduPeter Thomas
- Resource Type
- Journal article
- Publication Details
- Trends in endocrinology and metabolism, Vol.16(8), pp.362-367
- Publisher
- United States
- DOI
- 10.1016/j.tem.2005.08.005
- PMID
- 16125968
- ISSN
- 1043-2760
- eISSN
- 1879-3061
- Language
- English
- Date published
- 10/2005
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Surgery; Internal Medicine
- Record Identifier
- 9984051723802771
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