GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort

Jonathan T Heinzman; Karin F Hoth; Michael H Cho; Phuwanat Sakornsakolpat; Elizabeth A Regan; Barry J Make; Gregory L Kinney; Frederick S Wamboldt; Kristen E Holm; Nicholas Bormann; Julian Robles; Victor Kim; Anand S Iyer; Edwin K Silverman; James D Crapo; Shizhong Han; James B Potash; Gen Shinozaki; COPDGene Investigators

doi:10.1016/j.jad.2018.09.003

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GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort

Journal article

Peer reviewed

GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort

Jonathan T Heinzman, Karin F Hoth, Michael H Cho, Phuwanat Sakornsakolpat, Elizabeth A Regan, Barry J Make, Gregory L Kinney, Frederick S Wamboldt, Kristen E Holm, Nicholas Bormann, …

Journal of affective disorders, Vol.243, pp.16-22

01/15/2019

DOI: 10.1016/j.jad.2018.09.003

PMCID: PMC6186181

PMID: 30219690

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Abstract

•GWAS analysis of the COPDGene study showed several top hit SNPs.•Genes nearest top hit SNPs are associated with depression in the literature.•Such genes showed potential association with neurotransmitter networks.•The genes are expressed together in the brain, especially in the basal ganglia.•The COPDGene study provides future opportunities to study genetic risk factors of depression among smokers.

Systems Biology

Chronic obstructive pulmonary disease

Smokers

Genome-wide association study

Major depressive disorder

Details

Title: Subtitle: GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort
Creators: Jonathan T Heinzman - Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Karin F Hoth - Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Michael H Cho - Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA
Phuwanat Sakornsakolpat - Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA
Elizabeth A Regan - Department of Medicine, National Jewish Health, Denver, CO, USA
Barry J Make - Department of Medicine, National Jewish Health, Denver, CO, USA
Gregory L Kinney - Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA
Frederick S Wamboldt - Department of Medicine, National Jewish Health, Denver, CO, USA
Kristen E Holm - Department of Medicine, National Jewish Health, Denver, CO, USA
Nicholas Bormann - Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Julian Robles - Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Victor Kim - Department of Thoracic Medicine and Surgery, Temple University School of Medicine, Philadelphia, PA, USA
Anand S Iyer - Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Edwin K Silverman - Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA
James D Crapo - Department of Medicine, National Jewish Health, Denver, CO, USA
Shizhong Han - Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
James B Potash - Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Gen Shinozaki - Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
COPDGene Investigators
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.243, pp.16-22
DOI: 10.1016/j.jad.2018.09.003
PMID: 30219690
PMCID: PMC6186181
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier B.V
Grant note: DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: R01 HL089897, R01 HL089856; DOI: 10.13039/100008184, name: COPD Foundation
Language: English
Date published: 01/15/2019
Academic Unit: Psychiatry; Iowa Neuroscience Institute; Anesthesia; Neurosurgery
Record Identifier: 9984003468802771

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