Journal article
Gabapentin and memantine increases randomness of oscillatory waveform in ocular palatal tremor
Journal of computational neuroscience, Vol.49(3), pp.319-331
07/03/2020
DOI: 10.1007/s10827-020-00753-6
PMID: 32621105
Abstract
Syndrome of oculopalatal tremor (OPT) causes pendular nystagmus of the eyes and its disabling consequence on the visual system. Classic pharmacotherapeutic studies revealed reduction in the eye velocity of the oscillatory waveforms. Subjective improvement in vision, however, remains out of proportionately low. Elegant models depicting quasi-sinusoidal coarse oscillations of the eyes highlighted two distinct oscillators; one at the inferior olive causing primary 2 Hz oscillations, while the second, independent oscillator, at the cerebellum adding the randomness to the waveform. Here we examined whether pharmacotherapy affects the randomness of the oscillatory waveform. Horizontal, vertical, and torsional angular eye positions were measured independently from both eyes as six subjects with OPT directed gaze toward a straight-ahead target. The measurements were performed before administration of alpha-2-delta calcium channel blocker (gabapentin) or NMDA receptor antagonist (memantine) and after the subjects were treated with each of these drugs for at least 8 days. Amplitude and velocity of eye oscillations were reduced by gabapentin and memantine, but there was an increase in the waveform randomness. We found that the increase in randomness was proportionate to the amount of reduction in the waveform velocity or amplitude. Hierarchical clustering revealed distinct patterns of oscillatory waveforms, with each subject belonging to a specific cluster group. The pharmacotherapy changed the waveform clustering pattern of the waveform in each subject. We conclude that in addition to incomplete resolution of the oscillation intensity, increased randomness could be one of the reasons why there is not enough clinical difference in the patients’ visual quality.
Details
- Title: Subtitle
- Gabapentin and memantine increases randomness of oscillatory waveform in ocular palatal tremor
- Creators
- Wanchat Theeranaew - Louis Stokes Cleveland VA Medical CenterMatthew J Thurtell - University of IowaKenneth Loparo - Case Western Reserve UniversityAasef G Shaikh - Louis Stokes Cleveland VA Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of computational neuroscience, Vol.49(3), pp.319-331
- Publisher
- Springer US
- DOI
- 10.1007/s10827-020-00753-6
- PMID
- 32621105
- ISSN
- 0929-5313
- eISSN
- 1573-6873
- Grant note
- NA. / The American Academy of Neurology NA / American Parkinson Disease Association (http://dx.doi.org/10.13039/100006309) na / Dystonia Medical Research Foundation (http://dx.doi.org/10.13039/100001595)
- Language
- English
- Date published
- 07/03/2020
- Academic Unit
- Neurology; Ophthalmology and Visual Sciences
- Record Identifier
- 9984187228002771
Metrics
21 Record Views