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Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia
Journal article   Peer reviewed

Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia

Robert W Hurley, Debika Chatterjea, Meihua Rose Feng, Charles P Taylor and Donna L Hammond
Anesthesiology (Philadelphia), Vol.97(5), pp.1263-1273
11/2002
DOI: 10.1097/00000542-200211000-00033
PMID: 12411814

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Abstract

Gabapentin and pregabalin are anticonvulsants with antihyperalgesic effects in animal models of neuropathic and inflammatory nociception. This study characterized the manner in which gabapentin or pregabalin interacts with naproxen to suppress thermal hyperalgesia and inflammation in the carrageenan model of peripheral inflammation.
Calcium Channels - drug effects Analgesics - pharmacology Acetates - blood Amines Gabapentin Calcium - metabolism Naproxen - pharmacology Rats gamma-Aminobutyric Acid - pharmacology Male Pregabalin Naproxen - blood Rats, Sprague-Dawley Anti-Inflammatory Agents, Non-Steroidal - pharmacology Drug Synergism Animals Hyperalgesia - drug therapy Acetates - pharmacology Cyclohexanecarboxylic Acids gamma-Aminobutyric Acid - analogs & derivatives

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