Journal article
Gabapentin for smoking cessation: a preliminary investigation of efficacy
Nicotine & tobacco research, Vol.9(2), pp.291-298
02/2007
DOI: 10.1080/14622200601080307
PMID: 17365760
Abstract
Gabapentin affects the glutamate and gamma amino butyric acid (GABA) neurotransmitters through which it may facilitate smoking abstinence. To obtain preliminary estimates of efficacy of gabapentin for smoking cessation, we conducted a single-arm, open-label study of gabapentin, 1,800-mg/day administered in three equal divided doses for 8 weeks. A total of 50 adult smokers were enrolled. All participants received a brief behavioral intervention at each medication visit. A total of 37 participants completed all follow-up assessments. At end-of-treatment the biochemically confirmed point-prevalence and prolonged smoking abstinence rates were 28% (95% CI=16%-42%) and 24% (95% CI=13%-38%), respectively. At 6 months, the biochemically confirmed point-prevalence and prolonged smoking abstinence rates were 20% (95% CI=10%-34%) and 16% (95% CI=7%-29%), respectively. Among subjects who continued to smoke and completed the follow-up assessments, the reported number of cigarettes smoked per day (mean+/-standard deviation) was significantly less than at baseline: -10.0+/-8.2 (p<.001). Adverse effects were minor and well tolerated. Our results suggest that gabapentin may increase smoking abstinence. An adequately powered randomized clinical trial assessing different doses of this drug against a placebo would be the reasonable next step.
Details
- Title: Subtitle
- Gabapentin for smoking cessation: a preliminary investigation of efficacy
- Creators
- Amit Sood - Mayo Clinic College of Medicine, Rochester, MN 55905, USA. sood.amit@mayo.eduJon O EbbertDarrell R SchroederIvana T CroghanRicha SoodMark W Vander WegGilbert Y WongJ Taylor Hays
- Resource Type
- Journal article
- Publication Details
- Nicotine & tobacco research, Vol.9(2), pp.291-298
- DOI
- 10.1080/14622200601080307
- PMID
- 17365760
- NLM abbreviation
- Nicotine Tob Res
- ISSN
- 1462-2203
- eISSN
- 1469-994X
- Publisher
- England
- Language
- English
- Date published
- 02/2007
- Academic Unit
- Psychological and Brain Sciences; Injury Prevention Research Center; Community and Behavioral Health; Internal Medicine
- Record Identifier
- 9984063112102771
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