Journal article
Gain of Bcl-2 is more potent than Bax loss in regulating mammary epithelial cell survival in vivo
Cancer research (Chicago, Ill.), Vol.59(11), pp.2541-2545
1999
PMID: 10363969
Abstract
The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50% during the first stage and increased cell survival 70% during the second stage. Complete loss of Bax reduced apoptosis by 20% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo.
Details
- Title: Subtitle
- Gain of Bcl-2 is more potent than Bax loss in regulating mammary epithelial cell survival in vivo
- Creators
- K SCHORR - Department [K. S., P. A. F.] and Institute of Human Virology and Division of Infectious Disease, Department of Medicine [M. L., U. B-P., A. L, A. H., B. L, P. A. F. ], University of Maryland Medical School, Baltimore, Maryland 21201, United StatesMinglin Li - Institute of Human Virology and Division of Infectious Disease, Department of Medicine, University of Maryland Medical School, Baltimore, Maryland 21201, United StatesP. A FURTH - Department [K. S., P. A. F.] and Institute of Human Virology and Division of Infectious Disease, Department of Medicine [M. L., U. B-P., A. L, A. H., B. L, P. A. F. ], University of Maryland Medical School, Baltimore, Maryland 21201, United StatesU BAR-PELED - Institute of Human Virology and Division of Infectious Disease, Department of Medicine, University of Maryland Medical School, Baltimore, Maryland 21201, United StatesAlbert Lewis - Institute of Human Virology and Division of Infectious Disease, Department of Medicine, University of Maryland Medical School, Baltimore, Maryland 21201, United StatesA HEREDIA - Institute of Human Virology and Division of Infectious Disease, Department of Medicine, University of Maryland Medical School, Baltimore, Maryland 21201, United StatesBernadette Lewis - Institute of Human Virology and Division of Infectious Disease, Department of Medicine, University of Maryland Medical School, Baltimore, Maryland 21201, United StatesC. M KNUDSON - Howard Hughes Medical Institute and Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, United StatesS. J KORSMEYER - Howard Hughes Medical Institute and Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, United StatesR JÄGER - Forschungszentrum Karlsruhe, Institut fuer Genetik, Postfach 3640, 76021 Karlsruhe, GermanyH WEIHER - Institut fuer Diabetesforschung, Koelner Platz 1, 80804 Munich, Germany
- Resource Type
- Journal article
- Publication Details
- Cancer research (Chicago, Ill.), Vol.59(11), pp.2541-2545
- Publisher
- American Association for Cancer Research; Philadelphia, PA
- PMID
- 10363969
- ISSN
- 0008-5472
- eISSN
- 1538-7445
- Language
- English
- Date published
- 1999
- Academic Unit
- Pathology; Radiation Oncology
- Record Identifier
- 9984047890202771
Metrics
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