Gakolanone: a new benzophenone derivative from Garcinia kola Heckel stem-bark

Seide M Akoro; Olapeju O Aiyelaagbe; Patricia A Onocha; James B Gloer

doi:10.1080/14786419.2018.1528583

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Gakolanone: a new benzophenone derivative from Garcinia kola Heckel stem-bark

Journal article

Peer reviewed

Gakolanone: a new benzophenone derivative from Garcinia kola Heckel stem-bark

Seide M Akoro, Olapeju O Aiyelaagbe, Patricia A Onocha and James B Gloer

Natural Product Research, Vol.34(2), pp.241-250

01/17/2020

DOI: 10.1080/14786419.2018.1528583

PMID: 30449169

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Abstract

Gakolanone (3',5'-digeranyl-2',4',6',3-tetrahydroxybenzophenone; 1), a novel benzophenone derivative was isolated from the hexane extract of Garcinia kola Heckel stem-bark along with three known 3-8'' linked biflavonoids: 3'',4',4''',5,5'',7,7''-heptahydroxy-3,8''-biflavanone (2); 3'',4',5,5'',5''',7,7''-heptahydroxy-4-methoxy-3,8''-biflavanone (3) and 4',4''',5,5'',7,7''-hexahydroxy-3,8''-biflavanone (4) from the ethanol extract. The compounds were characterized primarily using 1 D and 2 D nuclear magnetic resonance spectroscopy and mass spectrometry and by comparing with literature. The compounds were subjected to in-vitro alpha-amylase enzyme inhibitory assay using DNSA (3,5-dinitrosalicylic acid) reagent with acarbose used as the standard drug. All the compounds were found to show alpha-amylase inhibitory activities with IC 50 of 21.4 ± 1.5, 9.9 ± 0.2, 15.3 ± 2.3, 12.9 ± 2.3 µg/mL respectively. All the compounds exhibited better alpha-amylase inhibitory activities than the standard drug, acarbose (IC 50 = 38.1 ± 8.3 µg/mL).

DNSA reagent

gakolanone

Garcinia kola stem-bark

benzophenone

biflavonoids

alpha-amylase inhibitory

Details

Title: Subtitle: Gakolanone: a new benzophenone derivative from Garcinia kola Heckel stem-bark
Creators: Seide M Akoro - Department of Chemical Sciences, Lagos State Polytechnic
Olapeju O Aiyelaagbe - Department of Chemistry, University of Ibadan
Patricia A Onocha - Department of Chemistry, University of Ibadan
James B Gloer - Department of Chemistry, University of Iowa
Resource Type: Journal article
Publication Details: Natural Product Research, Vol.34(2), pp.241-250
Publisher: Taylor & Francis
DOI: 10.1080/14786419.2018.1528583
PMID: 30449169
ISSN: 1478-6419
eISSN: 1478-6427
Grant note: Tertiary Education Trust Fund
Language: English
Date published: 01/17/2020
Academic Unit: Chemistry
Record Identifier: 9983985874402771

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