Journal article
Gallbladder Paraganglioma Associated with SDHD Mutation: a Potential Pitfall on 18F-FDOPA PET Imaging
Nuclear medicine and molecular imaging, Vol.53(2), pp.144-147
02/19/2019
DOI: 10.1007/s13139-018-0558-1
PMCID: PMC6473097
PMID: 31057686
Abstract
A 36-year-old male patient initially presented with hypertension, tinnitus, bilateral carotid masses, a right jugular foramen, and a periaortic arch mass with an elevated plasma dopamine level but an otherwise normal biochemical profile. On surveillance MRI 4 years after initial presentation, he was found to have a 2.2-cm T2 hyperintense lesion with arterial enhancement adjacent to the gallbladder, which demonstrated avidity on
68
Ga-DOTATATE PET/CT and retrospectively on
18
F-FDOPA PET/CT but was non-avid on
18
F-FDG PET/CT. Biochemical work-up including plasma catecholamines, metanephrines, and chromogranin A levels were found to be within normal limits. This lesion was surgically resected and was confirmed to be a paraganglioma (PGL) originating from the gallbladder wall on histopathology. Pheochromocytoma (PHEO) and PGL are rare tumors of the autonomic nervous system. Succinate dehydrogenase subunit D (
SDHD
) pathogenic variants of the succinate dehydrogenase complex are usually involved in parasympathetic, extra-adrenal, multifocal head, and neck PGLs. We report an unusual location of PGL in the gallbladder associated with
SDHD
mutation which could present as a potential pitfall on
18
F-FDOPA PET/CT as its normal excretion occurs through biliary system and gallbladder. This case highlights the superiority of
68
Ga-DOTATATE in comparison to
18
F-FDOPA and
18
F-FDG in the detection of
SDHD
-related parasympathetic PGL.
ClinicalTrials.gov Identifier:
NCT00004847
.
Details
- Title: Subtitle
- Gallbladder Paraganglioma Associated with SDHD Mutation: a Potential Pitfall on 18F-FDOPA PET Imaging
- Creators
- Zahraa Abdul Sater - 10 Center Dr., Bldg. 10, Bethesda, MD 20892 USAAbhishek Jha - National Institutes of HealthAdel Mandl - National Institutes of HealthSheila K. Mangelen - National Institutes of HealthJorge A. Carrasquillo - Memorial Sloan Kettering Cancer CenterAlexander Ling - National Institutes of HealthMelissa K. Gonzales - National Institutes of HealthOsorio Lopes Abath Neto - 10 Center Dr., Bldg. 10, Bethesda, MD 20892 USAMarkku Miettinen - National Institutes of HealthKaren T. Adams - National Institutes of HealthPavel Nockel - National Institutes of HealthMustapha El Lakis - National Institutes of HealthKarel Pacak - National Institutes of Health
- Resource Type
- Journal article
- Publication Details
- Nuclear medicine and molecular imaging, Vol.53(2), pp.144-147
- DOI
- 10.1007/s13139-018-0558-1
- PMID
- 31057686
- PMCID
- PMC6473097
- NLM abbreviation
- Nucl Med Mol Imaging
- ISSN
- 1869-3474
- eISSN
- 1869-3482
- Publisher
- Springer Berlin Heidelberg
- Grant note
- Z1AHD008735 / ;
- Language
- English
- Date published
- 02/19/2019
- Academic Unit
- Pathology
- Record Identifier
- 9984277458302771
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