Journal article
Gallbladder Scalloping, Mammillated Caudate Lobe, and Inferior Vena Cava Scalloping: Three Novel Ultrasound Signs of Cirrhosis
Academic radiology, Vol.25(11), pp.1374-1380
11/2018
DOI: 10.1016/j.acra.2018.02.011
PMID: 29602725
Abstract
We aimed to present three new ultrasound signs-gallbladder scalloping, mammillated caudate lobe, and inferior vena cava scalloping-and determine their accuracy in diagnosing liver cirrhosis.
A total of 201 consecutive patients with a history of chronic liver disease who had undergone ultrasound imaging and liver biopsy were identified. A senior ultrasound radiologist blindly reviewed the ultrasound examinations. Specificity, sensitivity, positive predictive value, and negative predictive value of diagnosing cirrhosis were calculated for all evaluated ultrasound signs and selected combinations of signs, using the liver biopsy results as the reference standard.
Of the 201 patients, 152 (76%) had either pathology-proven cirrhosis or significant fibrosis. Caudate lobe hypertrophy was the most specific (88%) and most positive predictor (90%) for cirrhosis, whereas mammillated caudate lobe was the most sensitive (78%). Inferior vena cava scalloping was the most specific (78%) of the three proposed ultrasound signs. When signs were combined, the presence of either gallbladder scalloping or liver surface nodularity was highly sensitive for cirrhosis (87%), whereas the presence of either gallbladder scalloping or inferior vena cava scalloping with caudate lobe hypertrophy was highly specific (93%).
Gallbladder scalloping, mammillated caudate lobe, and inferior vena cava scalloping are three novel signs that improve the accuracy of ultrasound in diagnosing cirrhosis.
Details
- Title: Subtitle
- Gallbladder Scalloping, Mammillated Caudate Lobe, and Inferior Vena Cava Scalloping: Three Novel Ultrasound Signs of Cirrhosis
- Creators
- Mohammad Amarneh - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA; Division of Interventional Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA. Electronic address: dr.amarneh@gmail.comAhmed Akhter - Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WisconsinM Zak Rajput - Mallinckrodt Institute of Radiology at Washington University, Saint Louis, MODouglas R LaBrecque - Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IAMonzer Abu-Yousef - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Academic radiology, Vol.25(11), pp.1374-1380
- Publisher
- United States
- DOI
- 10.1016/j.acra.2018.02.011
- PMID
- 29602725
- ISSN
- 1076-6332
- eISSN
- 1878-4046
- Language
- English
- Date published
- 11/2018
- Academic Unit
- Radiology; Stead Family Department of Pediatrics; Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984051591102771
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