Journal article
Gallbladder disease, cholecystectomy, and pancreatic cancer risk in the International Pancreatic Cancer Case-Control Consortium (PanC4)
European journal of cancer prevention, Vol.29(5), pp.408-415
04/21/2020
DOI: 10.1097/CEJ.0000000000000572
PMID: 32324646
Abstract
The association among gallbladder disease, cholecystectomy, and pancreatic cancer is unclear. Moreover, time interval between gallbladder disease or cholecystectomy and pancreatic cancer diagnosis is not considered in most previous studies.
To quantify the association among gallbladder disease, cholecystectomy, and pancreatic cancer, considering time since first diagnosis of gallbladder disease or cholecystectomy.
We used data from nine case-control studies within the Pancreatic Cancer Case-Control Consortium, including 5760 cases of adenocarcinoma of the exocrine pancreas and 8437 controls. We estimated pooled odds ratios and the corresponding 95% confidence intervals by estimating study-specific odds ratios through multivariable unconditional logistic regression models, and then pooling the obtained estimates using fixed-effects models.
Compared with patients with no history of gallbladder disease, the pooled odds ratio of pancreatic cancer was 1.69 (95% confidence interval, 1.51-1.88) for patients reporting a history of gallbladder disease. The odds ratio was 4.90 (95% confidence interval, 3.45-6.97) for gallbladder disease diagnosed <2 years before pancreatic cancer diagnosis and 1.11 (95% confidence interval, 0.96-1.29) when ≥2 years elapsed. The pooled odds ratio was 1.64 (95% confidence interval, 1.43-1.89) for patients who underwent cholecystectomy, as compared to those without cholecystectomy. The odds ratio was 7.00 (95% confidence interval, 4.13-11.86) for a surgery <2 years before pancreatic cancer diagnosis and 1.28 (95% confidence interval, 1.08-1.53) for a surgery ≥2 years before.
There appears to be no long-term effect of gallbladder disease on pancreatic cancer risk, and at most a modest one for cholecystectomy. The strong short-term association can be explained by diagnostic bias and reverse causation.
Details
- Title: Subtitle
- Gallbladder disease, cholecystectomy, and pancreatic cancer risk in the International Pancreatic Cancer Case-Control Consortium (PanC4)
- Creators
- Valentina Rosato - Unit of Medical Statistics and Biometry, National Cancer Institute, IRCCS FoundationEva Negri - Department of Biomedical and Clinical Sciences, University of MilanCristina Bosetti - Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, ItalyNúria Malats - Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO) and CIBERONC, Madrid, SpainPaulina Gomez-Rubio - Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO) and CIBERONC, Madrid, SpainPatrick Maisonneuve - Division of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCCS, Milan, ItalyAnthony B Miller - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, CanadaH Bas Bueno-de-Mesquita - Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UKPeter A Baghurst - Public Health, Women's and Children's Hospital, Adelaide, South Australia, AustraliaWitold Zatonski - Cancer Center and Institute of Oncology, Warsaw, PolandGloria M Petersen - Department of Health Sciences Research, Medicine and Medical Genetics, Mayo Clinic, Rochester, New York, USAGhislaine Scelo - International Agency for Research on Cancer (IARC), Lyon, FranceIvana Holcatova - Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech RepublicEleonora Fabianova - Faculty of Health, Catholic University, Ružomberok, Slovak RepublicDiego Serraino - Cancer Epidemiology Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, Aviano, ItalySara H Olson - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New YorkJesús Vioque - CIBER of Epidemiology and Public Health (CIBERESP), Madrid, SpainPagona Lagiou - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USAEric J Duell - Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, SpainPaolo Boffetta - The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York, USACarlo La Vecchia - Department of Clinical Sciences and Community Health, University of Milan, Milan, ItalyPancreatic Cancer Case-Control Consortium (PanC4)
- Contributors
- Michael A O'Rorke (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- European journal of cancer prevention, Vol.29(5), pp.408-415
- DOI
- 10.1097/CEJ.0000000000000572
- PMID
- 32324646
- ISSN
- 0959-8278
- eISSN
- 1473-5709
- Language
- English
- Date published
- 04/21/2020
- Academic Unit
- Epidemiology; Pathology
- Record Identifier
- 9984214847102771
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