Journal article
Game of microbes: the battle within - gut microbiota and multiple sclerosis
Gut microbes, Vol.16(1), 2387794
01/01/2024
DOI: 10.1080/19490976.2024.2387794
PMCID: PMC11313001
PMID: 39114974
Abstract
Multiple sclerosis (MS) is a chronic and progressive autoimmune disease of the central nervous system (CNS), with both genetic and environmental factors contributing to the pathobiology of the disease. While human leukocyte antigen (HLA) genes have emerged as the strongest genetic factor, consensus on environmental risk factors are lacking. Recently, trillions of microbes residing in our gut (microbiome) have emerged as a potential environmental factor linked with the pathobiology of MS as PwMS show gut microbial dysbiosis (altered gut microbiome). Thus, there has been a strong emphasis on understanding the factors (host and environmental) regulating the composition of the gut microbiota and the mechanism(s) through which gut microbes contribute to MS disease, especially through immune system modulation. A better understanding of these interactions will help harness the enormous potential of the gut microbiota as a therapeutic approach to treating MS.Multiple sclerosis (MS) is a chronic and progressive autoimmune disease of the central nervous system (CNS), with both genetic and environmental factors contributing to the pathobiology of the disease. While human leukocyte antigen (HLA) genes have emerged as the strongest genetic factor, consensus on environmental risk factors are lacking. Recently, trillions of microbes residing in our gut (microbiome) have emerged as a potential environmental factor linked with the pathobiology of MS as PwMS show gut microbial dysbiosis (altered gut microbiome). Thus, there has been a strong emphasis on understanding the factors (host and environmental) regulating the composition of the gut microbiota and the mechanism(s) through which gut microbes contribute to MS disease, especially through immune system modulation. A better understanding of these interactions will help harness the enormous potential of the gut microbiota as a therapeutic approach to treating MS.
Details
- Title: Subtitle
- Game of microbes: the battle within - gut microbiota and multiple sclerosis
- Creators
- Ti-Ara Turner - University of IowaPeter Lehman - University of IowaSudeep Ghimire - University of IowaShailesh K Shahi - University of IowaAshutosh Mangalam - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Gut microbes, Vol.16(1), 2387794
- DOI
- 10.1080/19490976.2024.2387794
- PMID
- 39114974
- PMCID
- PMC11313001
- ISSN
- 1949-0984
- eISSN
- 1949-0984
- Language
- English
- Date published
- 01/01/2024
- Academic Unit
- Pathology; Iowa Neuroscience Institute
- Record Identifier
- 9984696658002771
Metrics
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