Journal article
Gamma band pitch responses in human auditory cortex measured with magnetoencephalography
NeuroImage (Orlando, Fla.), Vol.59(2), pp.1904-1911
01/16/2012
DOI: 10.1016/j.neuroimage.2011.08.098
PMCID: PMC3236996
PMID: 21925281
Abstract
We have previously used direct electrode recordings in two human subjects to identify neural correlates of the perception of pitch (Griffiths, Kumar, Sedley et al., Direct recordings of pitch responses from human auditory cortex, Curr. Biol. 22 (2010), pp. 1128-1132). The present study was carried out to assess virtual-electrode measures of pitch perception based on non-invasive magnetoencephalography (MEG). We recorded pitch responses in 13 healthy volunteers using a passive listening paradigm and the same pitch-evoking stimuli (regular interval noise; RIN) as in the previous study. Source activity was reconstructed using a beamformer approach, which was used to place virtual electrodes in auditory cortex. Time-frequency decomposition of these data revealed oscillatory responses to pitch in the gamma frequency band to occur, in Heschl's gyrus, from 60 Hz upwards. Direct comparison of these pitch responses to the previous depth electrode recordings shows a striking congruence in terms of spectrotemporal profile and anatomical distribution. These findings provide further support that auditory high gamma oscillations occur in association with RIN pitch stimuli, and validate the use of MEG to assess neural correlates of normal and abnormal pitch perception. (C) 2011 Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- Gamma band pitch responses in human auditory cortex measured with magnetoencephalography
- Creators
- William Sedley - Newcastle UniversitySundeep Teki - Wellcome Centre for Human NeuroimagingSukhbinder Kumar - Wellcome Centre for Human NeuroimagingTobias Overath - UCL Ear InstituteGareth R. Barnes - Wellcome Centre for Human NeuroimagingTimothy D. Griffiths - Newcastle University
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.59(2), pp.1904-1911
- Publisher
- Elsevier
- DOI
- 10.1016/j.neuroimage.2011.08.098
- PMID
- 21925281
- PMCID
- PMC3236996
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Number of pages
- 8
- Grant note
- 091681; 091593 / Wellcome Trust; European Commission ACF-2009-01-006 / National Institute for Health Research; National Institute for Health Research (NIHR)
- Language
- English
- Date published
- 01/16/2012
- Academic Unit
- Psychological and Brain Sciences; Neurosurgery
- Record Identifier
- 9984304036102771
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