Ganciclovir-induced encephalopathy in a bone marrow transplant recipient

A Sharathkumar; P. J Shaw

doi:10.1038/sj.bmt.1701933

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Ganciclovir-induced encephalopathy in a bone marrow transplant recipient

Journal article

Open access

Peer reviewed

Ganciclovir-induced encephalopathy in a bone marrow transplant recipient

A Sharathkumar and P. J Shaw

Bone marrow transplantation (Basingstoke), Vol.24(4), pp.421-423

1999

DOI: 10.1038/sj.bmt.1701933

PMID: 10467333

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Abstract

Ganciclovir is widely used as prophylactic and pre-emptive therapy, as well as treatment, for CMV infection following BMT. We report a case treated with ganciclovir 5 days a week. Following escalation of the ganciclovir dose to a twice daily dose to treat CMV antigenaemia, he developed encephalopathy. His encephalopathy resolved with withdrawal of ganciclovir. Ganciclovir encephalopathy has been described in other groups of patients but has not been reported following BMT to date. With its widespread use this complication is likely to be seen more often.

Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy

Biological and medical sciences

Bone marrow, stem cells transplantation. Graft versus host reaction

Drug toxicity and drugs side effects treatment

Medical sciences

Pharmacology. Drug treatments

Toxicity: nervous system and muscle

Transfusions. Complications. Transfusion reactions. Cell and gene therapy

Details

Title: Subtitle: Ganciclovir-induced encephalopathy in a bone marrow transplant recipient
Creators: A Sharathkumar - Children's Hospital at Westmead
P. J Shaw - Children's Hospital at Westmead
Resource Type: Journal article
Publication Details: Bone marrow transplantation (Basingstoke), Vol.24(4), pp.421-423
DOI: 10.1038/sj.bmt.1701933
PMID: 10467333
NLM abbreviation: Bone Marrow Transplant
ISSN: 0268-3369
eISSN: 1476-5365
Publisher: Nature Publishing Group
Language: English
Date published: 1999
Academic Unit: Stead Family Department of Pediatrics; Hematology/Oncology
Record Identifier: 9984353888602771

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