Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient

J E Julin; J H van Burik; W Krivit; C Webb; C J Holman; H B Clark; H H Balfour Jr

doi:10.1034/j.1399-3062.2002.02005.x

Back

Journal article

Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient

J E Julin, J H van Burik, W Krivit, C Webb, C J Holman, H B Clark and H H Balfour Jr

Transplant infectious disease, Vol.4(4), pp.201-206

12/2002

DOI: 10.1034/j.1399-3062.2002.02005.x

PMID: 12535263

View Online

Abstract

A 20-year-old patient, who received a bone marrow transplant in order to treat metachromatic leukodystrophy (MLD), succumbed to cytomegalovirus (CMV) encephalitis. After CMV viremia developed, the patient received ganciclovir, but he was switched to foscarnet when ganciclovir resistance was suspected. Foscarnet was discontinued because of concern about its potential central nervous system toxicity. Autopsy samples of brain and cerebrospinal fluid contained CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. No foscarnet resistance mutations were found.

Cytomegalovirus - genetics

Antiviral Agents - therapeutic use

Humans

Drug Resistance, Viral

Leukodystrophy, Metachromatic - therapy

Male

Encephalitis, Viral - drug therapy

Cytomegalovirus - immunology

Cytomegalovirus Infections - drug therapy

Bone Marrow Transplantation - adverse effects

Cytomegalovirus Infections - etiology

Ganciclovir - therapeutic use

Adult

Cytomegalovirus Infections - pathology

Encephalitis, Viral - pathology

Foscarnet - therapeutic use

Encephalitis, Viral - etiology

Details

Title: Subtitle: Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient
Creators: J E Julin - Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
J H van Burik
W Krivit
C Webb
C J Holman
H B Clark
H H Balfour Jr
Resource Type: Journal article
Publication Details: Transplant infectious disease, Vol.4(4), pp.201-206
Publisher: Denmark
DOI: 10.1034/j.1399-3062.2002.02005.x
PMID: 12535263
ISSN: 1398-2273
eISSN: 1399-3062
Grant note: AI27661 / NIAID NIH HHS N01-AI-62554 / NIAID NIH HHS N01-AI-15113 / NIAID NIH HHS N01-AI-65306 / NIAID NIH HHS
Language: English
Date published: 12/2002
Academic Unit: Pathology
Record Identifier: 9984047979002771

Metrics

9 Record Views

See more details