Journal article
Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice
Hypertension (Dallas, Tex. 1979), Vol.43(2), pp.312-316
2004
DOI: 10.1161/01.HYP.0000111835.16662.43
PMID: 14699002
Abstract
In addition to central nervous system actions, angiotensin (Ang) II may increase sympathetic nerve activity (SNA) via a direct action on sympathetic ganglia. We hypothesized that sympathetic ganglionic actions of endogenous Ang II contribute to SNA in transgenic mice that overexpress renin and angiotensinogen (R+A+ mice). Renal SNA and arterial pressure were recorded in anesthetized R+A+ and littermate control mice before and after ganglionic blockade, and after additional blockade of angiotensin type 1 (AT1) receptors with losartan. Ganglionic blockade essentially abolished SNA in control mice, but only reduced SNA to 47±18% of baseline in R+A+ mice. The residual SNA remaining after ganglionic blockade in R+A+ mice was reduced from 47±18% to 8±6% of baseline by losartan (P<0.05). The sympathoinhibitory response to losartan was accompanied by an enhanced decrease in arterial pressure in R+A+ mice compared with that observed in control mice. AT1 receptor expression in sympathetic ganglia, as measured by real-time reverse transcription–polymerase chain reaction, was increased ≈3-fold in R+A+ versus control mice. The results demonstrate that, as anticipated, essentially all of the renal postganglionic SNA in control mice is driven by preganglionic input. The major new finding is that Ang II–evoked ganglionic activity accounts for ≈40% of total SNA in R+A+ mice. The significant contribution of the direct ganglionic action of Ang II in R+A+ mice likely reflects both increased levels of Ang II and upregulation of AT1 receptors in sympathetic ganglia.
Details
- Title: Subtitle
- Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice
- Creators
- Xiuying Ma - Cardiovascular Center and the Department of Internal Medicine, The University of Iowa, Iowa City, Iowa City, Iowa, United StatesCurt D SIGMUND - Cardiovascular Center and the Department of Internal Medicine, The University of Iowa, Iowa City, Iowa City, Iowa, United StatesShawn D HINGTGEN - Cardiovascular Center and the Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa City, Iowa, United StatesXin Tian - Cardiovascular Center and the Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa City, Iowa, United StatesRobin L DAVISSON - Cardiovascular Center and the Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa City, Iowa, United StatesFrancois M ABBOUD - Cardiovascular Center and the Department of Internal Medicine, The University of Iowa, Iowa City, Iowa City, Iowa, United StatesMark W CHAPLEAU - Cardiovascular Center and the Department of Internal Medicine, The University of Iowa, Iowa City, Iowa City, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.43(2), pp.312-316
- DOI
- 10.1161/01.HYP.0000111835.16662.43
- PMID
- 14699002
- NLM abbreviation
- Hypertension
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Publisher
- Lippincott; Philadelphia, PA; Hagerstown, MD
- Language
- English
- Date published
- 2004
- Academic Unit
- Molecular Physiology and Biophysics; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025465802771
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