Journal article
Ganglioside and monosaccharide inhibition of nonspecific lymphocyte mitogenicity by group A streptococcal pyrogenic exotoxins
Infection and immunity, Vol.27(1), pp.276-279
01/1980
DOI: 10.1128/IAI.27.1.276-279.1980
PMCID: PMC550757
PMID: 6987174
Abstract
Group A streptococcal pyrogenic exotoxins (SPE) types A, B, and C are potent nonspecific lymphocyte mitogens. The mitogenicity of these exotoxins was inhibited by gangliosides and sialic acid, whereas concanavalin A was unaffected. The capacity of both concanavalin A and SPE-A to stimulate lymphocytes was suppressed by alpha-methyl-D-mannopyranoside. Galactose reduced the activity of SPE-C. The sugars, glucose, N-acetylglucosamine, alpha-methyl-D-glucopyranoside, and fucose, did not affect SPE mitogenicity.
Details
- Title: Subtitle
- Ganglioside and monosaccharide inhibition of nonspecific lymphocyte mitogenicity by group A streptococcal pyrogenic exotoxins
- Creators
- Patrick M SchlievertDiane J SchoettleDennis W Watson
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.27(1), pp.276-279
- DOI
- 10.1128/IAI.27.1.276-279.1980
- PMID
- 6987174
- PMCID
- PMC550757
- NLM abbreviation
- Infect Immun
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Publisher
- United States
- Language
- English
- Date published
- 01/1980
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001224502771
Metrics
23 Record Views