Journal article
Ganglioside patterns mature at different rates in functionally related subregions of the rat pons
Developmental neuroscience, Vol.24(6), pp.478-484
2002
DOI: 10.1159/000069358
PMID: 12697985
Abstract
Gangliosides are known to be developmentally regulated and regionally variable, but these variations have not been shown to occur among precisely defined nuclei of the brain in relation to either aging or function. We have sought to correlate changes in ganglioside distribution with age-related changes in highly specific brain regions known to control a common function, the regulation of rapid eye movement sleep architecture. Gangliosides were extracted and quantified from micropunched regions of the locus coeruleus, dorsal raphe, laterodorsal tegmentum, pedunculopontine tegmentum and the general region of the pons containing these nuclei in young adult (3 months), adult (12 months), and aged (24 months) rats. The ganglioside distribution patterns were generally characteristic of the pons as a whole, but showed a high level of differentiation in time course at specific anatomical sites.
Details
- Title: Subtitle
- Ganglioside patterns mature at different rates in functionally related subregions of the rat pons
- Creators
- Donna M Byers - The University of Texas at El PasoLouis N Irwin - The University of Texas at El PasoRafael Cabeza
- Resource Type
- Journal article
- Publication Details
- Developmental neuroscience, Vol.24(6), pp.478-484
- DOI
- 10.1159/000069358
- PMID
- 12697985
- ISSN
- 0378-5866
- eISSN
- 1421-9859
- Grant note
- G12-RRO8124 / NCRR NIH HHS
- Language
- English
- Date published
- 2002
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984695680402771
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