Journal article
Gas chromatographic separation of methoxylated polychlorinated biphenyl atropisomers
JOURNAL OF CHROMATOGRAPHY A, Vol.1207(1-2), pp.146-154
10/17/2008
DOI: 10.1016/j.chroma.2008.08.044
PMCID: PMC2579784
PMID: 18760792
Abstract
Several polychlorinated biphenyls (PCBs) and their hydroxylated metabolites display axial chirality. Here we describe an enantioselective, gas chromatographic separation of methylated derivatives of hydroxylated (OH-)PCB atropisomers (MeO-PCB) using a chemically bonded beta-cyclodextrin column (Chirasil-Dex). The atropisomers of several MeO-PCBs could be separated on this column with resolutions ranging from 0.42 to 0.87 under isothermal or temperature-programmed conditions. In addition, the enantiomeric fraction of OH-PCB 136 metabolites was determined in male and female rats treated with racemic PCB 136. The methylated derivatives of two OH-PCB 136 metabolites showed an enantiomeric enrichment in liver tissue, whereas PCB 136 itself was near racemic. (C) 2008 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Gas chromatographic separation of methoxylated polychlorinated biphenyl atropisomers
- Creators
- Izabela Kania-Korwel - University of IowaSandhya M. Vyas - University of IowaYang Song - University of IowaHans-Joachim Lehmler - University of Iowa
- Resource Type
- Journal article
- Publication Details
- JOURNAL OF CHROMATOGRAPHY A, Vol.1207(1-2), pp.146-154
- DOI
- 10.1016/j.chroma.2008.08.044
- PMID
- 18760792
- PMCID
- PMC2579784
- NLM abbreviation
- J Chromatogr A
- ISSN
- 0021-9673
- eISSN
- 1873-3778
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- ES06694 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA ES05605; ES013661; ES012475 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) K25ES012475 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Language
- English
- Date published
- 10/17/2008
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute; Iowa Superfund Research Program
- Record Identifier
- 9984285537502771
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