Journal article
Gastric Cancer in Alaska Native and American Indian People Living in Alaska, 1990-2017
Clinical and translational gastroenterology, Vol.12(7), 00374
07/01/2021
DOI: 10.14309/ctg.0000000000000374
PMCID: PMC8221803
PMID: 34158461
Abstract
INTRODUCTION:Alaska Native (AN) people experience a high burden of gastric cancer compared with other US Native and non-Native populations. Previous reports have suggested that gastric cancer in AN people occurs at a younger age and is a more aggressive pathologic type. We evaluated all cases of gastric cancer in AN people from 1990 to 2017 and compared the epidemiologic and pathologic characteristics with the gastric cancers that occurred in the same time in the US white (USW) population.METHODS:Cancer data were collected by the Alaska Native Tumor Registry and National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Comparisons were performed looking at the age and sex distribution of the affected AN and USW people, as well as the cancer characteristics, including the location, stage, and pathology.RESULTS:The age distribution was significantly different between AN and USW patients (P < 0.001), with a greater proportion of AN people diagnosed younger than 40 years (11% vs 3%, P < 0.0001) and 40-59 years (37% vs 20%, P < 0.0001). In addition, a greater proportion of AN people were diagnosed with distant stage cancer (AN: 48% and USW: 35%, P < 0.0001). The age-adjusted rate of gastric cancer in the AN population was significantly higher than the USW population (20.8 vs 6.7 per 100,000 persons, P < 0.0001). Although there has been a significant decrease in the gastric cancer incidence rate in the USW population, no significant change in incidence was seen in the AN population.DISCUSSION:This study highlights the disproportionate burden of gastric cancer in the AN population. Further work is needed to address and understand this disparity.
Details
- Title: Subtitle
- Gastric Cancer in Alaska Native and American Indian People Living in Alaska, 1990-2017
- Creators
- Leisha D. Nolen - National Center for Emerging and Zoonotic Infectious DiseasesSara Bressler - National Center for Emerging and Zoonotic Infectious DiseasesStephen M. Vindigni - Alaska Native Tribal Health ConsortiumKeri Miller - Alaska Native Tribal Health ConsortiumSarah Nash - Alaska Native Tribal Health Consortium
- Resource Type
- Journal article
- Publication Details
- Clinical and translational gastroenterology, Vol.12(7), 00374
- DOI
- 10.14309/ctg.0000000000000374
- PMID
- 34158461
- PMCID
- PMC8221803
- NLM abbreviation
- Clin Transl Gastroenterol
- eISSN
- 2155-384X
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- National Cancer Institute (NCI) Surveillance, Epidemiology and End Results Program HHSN26120130010I; HHSN26100005 / NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 07/01/2021
- Academic Unit
- Epidemiology; Center for Social Science Innovation; Community and Behavioral Health
- Record Identifier
- 9984512059202771
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