Journal article
Gastric inhibitory polypeptide receptor (GIPR) is a promising target for imaging and therapy in neuroendocrine tumors
Surgery, Vol.154(6), pp.1206-1214
12/2013
DOI: 10.1016/j.surg.2013.04.052
PMCID: PMC3881364
PMID: 24238043
Abstract
Ligands binding the somatostatin receptor type 2 (SSTR2) are useful for imaging and treatment of neuroendocrine tumors (NETs), but not all tumors express high levels of these receptors. The aim of this study was to evaluate gene expression of new therapeutic targets in NETs relative to SSTR2.
RNA was extracted from 103 primary small bowel and pancreatic NETs, matched normal tissue, and 123 metastases. Expression of 12 candidate genes was measured by quantitative polymerase chain reaction normalized to internal controls; candidate gene expression was compared with SSTR2.
Relative to normal tissue, primary NET expression of SSTR2, GPR98, BRS3, GIPR, GRM1, and OPRK1 were increased by 3, 8, 13, 13, 17, and 20-fold, respectively. Similar changes were found in metastases. Although most candidate genes showed lesser absolute expressions than SSTR2, absolute GIPR expression was closest to SSTR2 (mean dCT 3.6 vs 2.7, P = .01). Absolute OPRK1 and OXTR expression varied greatly by primary tumor type and was close to SSTR2 in small bowel NETs but not pancreatic NETs.
Compared with the current treatment standard SSTR2, GIPR has only somewhat lesser absolute gene expression in tumor tissue but much lesser expression in normal tissue, making it a promising new target for NET imaging and therapy.
Details
- Title: Subtitle
- Gastric inhibitory polypeptide receptor (GIPR) is a promising target for imaging and therapy in neuroendocrine tumors
- Creators
- Scott K Sherman - Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IAJennifer C Carr - Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IADonghong Wang - Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IAM. Sue O’Dorisio - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IAThomas M O’Dorisio - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IAJames R Howe - Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Surgery, Vol.154(6), pp.1206-1214
- DOI
- 10.1016/j.surg.2013.04.052
- PMID
- 24238043
- PMCID
- PMC3881364
- NLM abbreviation
- Surgery
- ISSN
- 0039-6060
- eISSN
- 1532-7361
- Publisher
- Elsevier BV
- Grant note
- University of Iowa Institute for Clinical and Translational Science 5T32 #CA148062-03 / NIH
- Language
- English
- Date published
- 12/2013
- Academic Unit
- Stead Family Department of Pediatrics; Surgery; Endocrinology and Metabolism; Otolaryngology; Internal Medicine
- Record Identifier
- 9984051779902771
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