Journal article
Gastrostomy Tube Feeding in Extremely Low Birthweight Infants: Frequency, Associated Comorbidities, and Long-term Outcomes
The Journal of pediatrics, Vol.214, pp.41-46.e5
11/01/2019
DOI: 10.1016/j.jpeds.2019.06.066
PMCID: PMC6815700
PMID: 31427096
Abstract
Objective To assess the frequency of gastrostomy tube (GT) placement in extremely low birth weight (ELBW) infants, associated comorbidities, and long-term outcomes.
Study design Analysis of ELBW infants from 25 centers enrolled in the National Institute of Child Health and Human Development Neonatal Research Network's Generic Database and Follow-up Registry from 2006 to 2012. Frequency of GT placement before 18-22 months, demographic and medical factors associated with GT placement, and associated long-term outcomes at 18-22 months of corrected age were described. Associations between GT placement and neonatal morbidities and long-term outcomes were assessed with logistic regression after adjustment for center and common co-variables.
Results Of the 4549 ELBW infants included in these analyses, 333 (7.3%) underwent GT placement; 76% had the GT placed postdischarge. Of infants with GTs, 11 % had birth weights small for gestational age, 77% had bronchopulmonary dysplasia, and 29% severe intraventricular hemorrhage or periventricular leukomalacia. At follow-up, 56% of infants with a GT had weight <10th percentile, 61 % had neurodevelopmental impairment (NDI), and 55% had chronic breathing problems. After adjustment, small for gestational age, bronchopulmonary dysplasia, intraventricular hemorrhage/periventricular leukomalacia, poor growth, and NDI were associated with GT placement. Thirty-two percent of infants with GTs placed were taking full oral feeds at follow-up.
Conclusions GT placement is common in ELBW infants, particularly among those with severe neonatal morbidities. GT placement in this population was associated with poor growth, NDI, and chronic respiratory and feeding problems at follow-up. The frequency of GT placement postneonatal discharge indicates the need for close nutritional follow-up of ELBW infants.
Details
- Title: Subtitle
- Gastrostomy Tube Feeding in Extremely Low Birthweight Infants: Frequency, Associated Comorbidities, and Long-term Outcomes
- Creators
- Mollie G. Warren - Duke UniversityBarbara Do - RTI InternationalAbhik Das - RTI InternationalP. Brian Smith - Duke UniversityIra Adams-Chapman - Children's Healthcare of AtlantaSudarshan Jadcherla - Nationwide Children's HospitalErik A. Jensen - Children's Hospital of PhiladelphiaRicki F. Goldstein - Duke UniversityRonald N. Goldberg - Duke UniversityC. Michael Cotten - Duke UniversityEdward F. Bell - University of IowaWilliam F. Malcolm - Duke UniversityMichael S. Caplan - University of ChicagoAbbott R. Laptook - Brown UniversityMartin Keszler - Brown UniversityBetty R. Vohr - Brown UniversityAngelita M. Hensman - Brown UniversityBarbara Alksninis - Brown UniversityKristin M. Basso - Brown UniversityRobert Burke - Brown UniversityMelinda Caskey - Brown UniversityKatharine Johnson - Brown UniversityMary Lenore Keszler - Brown UniversityAndrea M. Knoll - Brown UniversityTheresa M. Leach - Brown UniversityEmilee Little - Brown UniversityElisabeth C. McGowan - Brown UniversityElisa Vieira - Brown UniversityVictoria E. Watson - Brown UniversitySuzy Ventura - Brown UniversityMichele C. Walsh - Case Western Reserve UniversityAnna Maria Hibbs - Case Western Reserve UniversityDeanne E. Wilson-Costello - Case Western Reserve UniversityNancy S. Newman - Case Western Reserve UniversityAllison H. Payne - Case Western Reserve UniversityBonnie S. Siner - Case Western Reserve UniversityMonika Bhola - Case Western Reserve UniversityGulgun Yalcinkaya - Case Western Reserve UniversityWilliam E. Truog - University of MissouriEugenia K. Pallotto - University of MissouriHoward W. Kilbride - University of MissouriCheri Gauldin - University of MissouriAnne Holmes - University of MissouriKathy Johnson - University of MissouriAllison Scott - University of MissouriKurt Schibler - Cincinnati Children's Hospital Medical CenterEdward F. Donovan - Cincinnati Children's Hospital Medical CenterCathy Grisby - Cincinnati Children's Hospital Medical CenterKate Bridges - Cincinnati Children's Hospital Medical CenterBarbara Alexander - Cincinnati Children's Hospital Medical CenterEstelle E. Fischer - Cincinnati Children's Hospital Medical CenterHolly L. Mincey - Cincinnati Children's Hospital Medical CenterJody Hessling - Cincinnati Children's Hospital Medical CenterTeresa L. Gratton - Cincinnati Children's Hospital Medical CenterLenora Jackson - Cincinnati Children's Hospital Medical CenterKristin Kirker - Cincinnati Children's Hospital Medical CenterGreg Muthig - Cincinnati Children's Hospital Medical CenterJean J. Steichen - Cincinnati Children's Hospital Medical CenterStacey Tepe - Cincinnati Children's Hospital Medical CenterKimberly Yolton - Cincinnati Children's Hospital Medical CenterPatricia L. Ashley - Duke UniversityKathy J. Auten - Duke UniversityKimberley A. Fisher - Duke UniversitySandra Grimes - Duke UniversityKathryn E. Gustafson - Duke UniversityMelody B. Lohmeyer - Duke UniversityJoanne Finkle - Duke UniversityMatthew M. Laughon - Duke UniversityCarl L. Bose - Duke UniversityJanice Bernhardt - Duke UniversityGennie Bose - Duke UniversityDiane Warner - Duke UniversityJanice Wereszczak - Duke UniversityDavid P. Carlton - Emory UniversityBarbara J. Stoll - Emory UniversityEllen C. Hale - Emory UniversityYvonne Loggins - Emory UniversityAnn Blackwelder - Emory UniversityLynn C. Wineski - Emory UniversityMaureen Mulligan LaRossa - Emory UniversitySheena L. Carter - Emory UniversityRosemary D. Higgins - Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Rockville, MD USAStephanie Wilson Archer - Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Rockville, MD USAGregory M. Sokol - Indiana UniversityBrenda B. Poindexter - Indiana UniversityAnna M. Dusick - Indiana UniversityLu-Ann Papile - Indiana UniversitySusan Gunn - Indiana UniversityFaithe Hamer - Indiana UniversityHeidi M. Harmon - Indiana UniversityDianne E. Herron - Indiana UniversityAbbey C. Hines - Indiana UniversityCarolyn Lytle - Indiana UniversityHeike M. Minnich - Indiana UniversityLucy Smiley - Indiana UniversityLeslie Dawn Wilson - Indiana UniversityKathleen A. Kennedy - The University of Texas Health Science Center at HoustonJon E. Tyson - The University of Texas Health Science Center at HoustonGeorgia E. McDavid - The University of Texas Health Science Center at HoustonNora Alaniz - The University of Texas Health Science Center at HoustonJulie Arldt-McAlister - The University of Texas Health Science Center at HoustonKatrina Burson - The University of Texas Health Science Center at HoustonAllison G. Dempsey - The University of Texas Health Science Center at HoustonAndrea F. Duncan - The University of Texas Health Science Center at HoustonPatricia W. Evans - The University of Texas Health Science Center at HoustonCharles E. Green - The University of Texas Health Science Center at HoustonBeverly Foley Harris - The University of Texas Health Science Center at HoustonMargarita Jiminez - The University of Texas Health Science Center at HoustonJanice John - The University of Texas Health Science Center at HoustonPatrick M. Jones - The University of Texas Health Science Center at HoustonLayne M. Lillie - The University of Texas Health Science Center at HoustonAnna E. Lis - The University of Texas Health Science Center at HoustonSara C. Martin - The University of Texas Health Science Center at HoustonBrenda H. Morris - The University of Texas Health Science Center at HoustonM. Layne Poundstone - The University of Texas Health Science Center at HoustonShawna Rodgers - The University of Texas Health Science Center at HoustonSaba Siddiki - The University of Texas Health Science Center at HoustonMaegan C. Simmons - The University of Texas Health Science Center at HoustonDaniel Sperry - The University of Texas Health Science Center at HoustonPatti L. Pierce Tate - The University of Texas Health Science Center at HoustonSharon L. Wright - The University of Texas Health Science Center at HoustonPablo J. Sanchez - Nationwide Childrens Hosp, Columbus, OH USALeif D. Nelin - Nationwide Childrens Hosp, Columbus, OH USAPatricia Luzader - Nationwide Childrens Hosp, Columbus, OH USAChristine A. Fortney - Nationwide Childrens Hosp, Columbus, OH USAGail E. Besner - Nationwide Childrens Hosp, Columbus, OH USANehal A. Parikh - Nationwide Childrens Hosp, Columbus, OH USADennis Wallace - RTI (United States)Marie G. Gantz - RTI (United States)W. Kenneth Poole - RTI (United States)Jamie E. Newman - RTI (United States)Jeanette O'Donnell Auman - RTI (United States)Margaret M. Crawford - RTI (United States)Jenna Gabrio - RTI (United States)Carolyn M. Petrie Huitema - RTI (United States)Kristin M. Zaterka-Baxter - RTI (United States)Krisa P. Van Meurs - Stanford UniversityDavid K. Stevenson - Stanford UniversitySusan R. Hintz - Stanford UniversityM. Bethany Ball - Stanford UniversityAlexis S. Davis - Stanford UniversityAndrew W. Palmquist - Stanford UniversityMelinda S. Proud - Stanford UniversityBarbara Bentley - Stanford UniversityElizabeth Bruno - Stanford UniversityMaria Elena DeAnda - Stanford UniversityAnne M. DeBattista - Stanford UniversityBeth Earhart - Stanford UniversityLynne C. Huffman - Stanford UniversityJean G. Kohn - Stanford UniversityCasey Krueger - Stanford UniversityHali E. Weiss - Stanford UniversityIvan D. Frantz - Tufts Medical CenterJohn M. Fiascone - Tufts Medical CenterBrenda L. MacKinnon - Tufts Medical CenterAnne Furey - Tufts Medical CenterEllen Nylen - Tufts Medical CenterCecelia E. Sibley - Tufts Medical CenterAna K. Brussa - Tufts Medical CenterWaldemar A. Carlo - University of AlabamaNamasivayam Ambalavanan - University of AlabamaMyriam Peralta-Carcelen - University of AlabamaMonica Collins - University of AlabamaShirley S. Cosby - University of AlabamaFred J. Biasini - University of AlabamaKristen C. Johnston - University of AlabamaKathleen G. Nelson - University of AlabamaCryshelle S. Patterson - University of AlabamaVivien A. Phillips - University of AlabamaSally Whitley - University of AlabamaUday Devaskar - Mattel Children's HospitalMeena Garg - Mattel Children's HospitalIsabell B. Purdy - Mattel Children's HospitalTeresa Chanlaw - Mattel Children's HospitalRachel Geller - Mattel Children's HospitalNeil N. Finer - University of California San DiegoYvonne E. Vaucher - University of California San DiegoDavid Kaegi - University of California San DiegoMaynard R. Rasmussen - University of California San DiegoKathy Arnell - University of California San DiegoClarence Demetrio - University of California San DiegoMartha G. Fuller - University of California San DiegoWade Rich - University of California San DiegoTarah T. Colaizy - University of IowaMichael J. Acarregui - Univ Iowa, Cedar Rapids, IA USAJane E. Brumbaugh - University of IowaDan L. Ellsbury - University of IowaJohn A. Widness - University of IowaKaren J. Johnson - University of IowaDonia B. Campbell - University of IowaDiane L. Eastman - Univ Iowa, Cedar Rapids, IA USAJacky R. Walker - University of IowaShahnaz Duara - University of MiamiCharles R. Bauer - University of MiamiRuth Everett-Thomas - University of MiamiSylvia Fajardo-Hiriart - University of MiamiArielle Rigaud - University of MiamiMaria Calejo - University of MiamiSilvia M. Frade Eguaras - University of MiamiMichelle Harwood Berkowits - University of MiamiAndrea Garcia - University of MiamiHelina Pierre - University of MiamiAlexandra Stoerger - University of MiamiKristi L. Watterberg - University of New MexicoJean R. Lowe - University of New MexicoJanell F. Fuller - University of New MexicoRobin K. Ohls - University of New MexicoConra Backstrom Lacy - University of New MexicoRebecca Montman - University of New MexicoSandra Sundquist Beauman - University of New MexicoBarbara Schmidt - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USAHaresh Kirpalani - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USASara B. DeMauro - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USAAasma S. Chaudhary - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USASoraya Abbasi - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USAToni Mancini - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USADara M. Cucinotta - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USAJudy C. Bernbaum - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USAMarsha Gerdes - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USAHallam Hurt - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USACarl T. D'Angio - University of RochesterDale L. Phelps - University of RochesterRonnie Guillet - University of RochesterSatyan Lakshminrusimha - University of RochesterJulie Babish Johnson - University of RochesterLinda J. Reubens - University of RochesterCassandra A. Horihan - University of RochesterDiane Hust - University of RochesterRosemary L. Jensen - University of RochesterEmily Kushner - University of RochesterJoan Merzbach - University of RochesterGary J. Myers - University of RochesterHolly I. M. Wadkins - University of RochesterStephanie Guilford - University of RochesterDeanna Maffett - University of RochesterOsman Farooq - University of RochesterDiane Prinzing - University of RochesterAnne Marie Reynolds - University of RochesterMary Rowan - University of RochesterMichael G. Sacilowski - University of RochesterAshley Williams - University of RochesterKaren Wynn - University of RochesterKelley Yost - University of RochesterWilliam Zorn - University of RochesterLauren Zwetsch - University of RochesterMyra H. Wyckoff - The University of Texas Southwestern Medical CenterLuc P. Brion - The University of Texas Southwestern Medical CenterRoy J. Heyne - The University of Texas Southwestern Medical CenterWalid A. Salhab - The University of Texas Southwestern Medical CenterCharles R. Rosenfeld - The University of Texas Southwestern Medical CenterDiana M. Vasil - The University of Texas Southwestern Medical CenterLijun Chen - The University of Texas Southwestern Medical CenterAlicia Guzman - The University of Texas Southwestern Medical CenterGaynelle Hensley - The University of Texas Southwestern Medical CenterMelissa H. Leps - The University of Texas Southwestern Medical CenterNancy A. Miller - The University of Texas Southwestern Medical CenterJanet S. Morgan - The University of Texas Southwestern Medical CenterSally S. Adams - The University of Texas Southwestern Medical CenterCatherine Twell Boatman - The University of Texas Southwestern Medical CenterElizabeth T. Heyne - The University of Texas Southwestern Medical CenterLinda A. Madden - The University of Texas Southwestern Medical CenterLizette E. Lee - The University of Texas Southwestern Medical CenterRoger G. Faix - University of UtahBradley A. Yoder - University of UtahKaren A. Osborne - University of UtahCynthia Spencer - University of UtahKimberlee Weaver-Lewis - University of UtahShawna Baker - University of UtahKane Bird - University of UtahJill Burnett - University of UtahMichael Steffen - University of UtahJennifer J. Jensen - University of UtahSarah Winter - University of UtahKaren Zanetti - University of UtahT. Michael O'Shea - Wake Forest UniversityRobert G. Dillard - Wake Forest UniversityLisa K. Washburn - Wake Forest UniversityBarbara G. Jackson - Wake Forest UniversityNancy Peters - Wake Forest UniversityKorinne Chiu - Wake Forest UniversityDeborah Evans Allred - Wake Forest UniversityDonald J. Goldstein - Wake Forest UniversityRaquel Halfond - Wake Forest UniversityCarroll Peterson - Wake Forest UniversityEllen L. Waldrep - Wake Forest UniversityCherrie D. Welch - Wake Forest UniversityMelissa Whalen Morris - Wake Forest UniversityGail Wiley Hounshell - Wake Forest UniversitySeetha Shankaran - Wayne State UniversityAthina Pappas - Wayne State UniversityJohn Barks - Wayne State UniversityRebecca Bara - Wayne State UniversityLaura A. Goldston - Wayne State UniversityGirija Natarajan - Wayne State UniversityMonika Bajaj - Wayne State UniversitySanjay Chawla - Wayne State UniversityLilia C. De Jesus - Wayne State UniversityBeena G. Sood - Wayne State UniversityMary Christensen - Wayne State UniversityStephanie A. Wiggins - Wayne State UniversityDiane White - Wayne State UniversityRichard A. Ehrenkranz - Yale UniversityHarris Jacobs - Yale UniversityChristine G. Butler - Yale UniversityPatricia Cervone - Yale UniversitySheila Greisman - Yale UniversityMonica Konstantino - Yale UniversityJoAnn Poulsen - Yale UniversityJanet Taft - Yale UniversityJoanne Williams - Yale UniversityElaine Romano - Yale UniversityEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.214, pp.41-46.e5
- DOI
- 10.1016/j.jpeds.2019.06.066
- PMID
- 31427096
- PMCID
- PMC6815700
- NLM abbreviation
- J Pediatr
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- U10 HD036790; UG1 HD087226; U10 HD053124; UG1 HD021385; U10 HD040521; UG1 HD027853; UG1 HD068244; UG1 HD040689; UG1 HD068284; UG1 HD087229; U10 HD053119; UG1 HD068270; UG1 HD068263; U10 HD040498; UG1 HD034216; U24 HD095254; UG1 HD068278; U10 HD021373; UG1 HD053109; UG1 HD027904; UG1 HD021364; U10 HD068263; UG1 HD040492; UG1 HD027856; U10 HD021397; UG1 HD027880; U10 HD027871; U10 HD053109; U10 HD040461; UG1 HD053089; UG1 HD027851 / NICHD NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) UG1HD053089 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) UL1 TR000042 / NCATS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) M01 RR000997; M01 RR000070; M01 RR000750; M01 RR016587; M01 RR008084; M01 RR000039; M01 RR000030; M01 RR000080; M01 RR000064; UL1 RR025764; M01 RR000633; M01 RR007122 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Language
- English
- Date published
- 11/01/2019
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354037302771
Metrics
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