Journal article
Gemtuzumab Ozogamicin (CMA-676, Mylotarg) for the treatment of CD33+ acute myeloid leukemia
Anti-cancer drugs, Vol.13(7), pp.685-692
08/2002
DOI: 10.1097/00001813-200208000-00002
PMID: 12187324
Abstract
Gemtuzumab Ozogamicin (GO, CMA-676) is a monoclonal antibody against the cellular surface antigen CD33 conjugated with the cytotoxic antibiotic calicheamicin. In the beginning of 2000 it obtained US Food and Drug Administration approval for the treatment of refractory acute myeloid leukemia (AML) expressing CD33 in patients older than 60 years who are not candidates for other chemotherapy. After ligation with the CD33 on the cell surface, GO is internalized and hydrolyzed. Its two components are released into the cytoplasm and calicheamicin enters the nucleus where it associates with the DNA, causing double helix breaks and finally cell death. GO is in general well tolerated. The most frequent adverse effect observed is myelotoxicity, with prolonged neutropenia and thrombocytopenia. Veno-occlusive disease of the liver is a less frequent but severe adverse effect. A phase II study points towards a percentage of overall hematologic response around 30% in the setting of refractory or relapsed disease. Future phase III trials will show the most suitable place of GO in the treatment of AML.
Details
- Title: Subtitle
- Gemtuzumab Ozogamicin (CMA-676, Mylotarg) for the treatment of CD33+ acute myeloid leukemia
- Creators
- Ioannis A Voutsadakis - Institut Gustave Roussy
- Resource Type
- Journal article
- Publication Details
- Anti-cancer drugs, Vol.13(7), pp.685-692
- DOI
- 10.1097/00001813-200208000-00002
- PMID
- 12187324
- ISSN
- 0959-4973
- Language
- English
- Date published
- 08/2002
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806509702771
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