Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Giuseppe De Luca; Stephane Manzo-Silberman; Magdy Algowhary; Berat Uguz; Dinaldo C. Oliveira; Vladimir Ganyukov; Oliver Busljetik; Miha Cercek; Lisette Okkels; Poay Huan Loh; Lucian Calmac; Gerard Roura i Ferrer; Alexandre Quadros; Marek Milewski; Fortunato Scotto di Uccio; Clemens von Birgelen; Francesco Versaci; Jurrien Ten Berg; Gianni Casella; Aaron Wong Sung Lung; Petr Kala; Jose Luis Diez Gil; Xavier Carrillo; Maurits Dirksen; Victor Becerra; Michael Kang-yin Lee; Dafsah Arifa Juzar; Rodrigo de Moura Joaquim; Roberto Paladino; Davor Milicic; Periklis Davlouros; Nikola Bakraceski; Filippo Zilio; Luca Donazzan; Adriaan Kraaijeveld; Gennaro Galasso; Lux Arpad; Lucia Marinucci; Vincenzo Guiducci; Maurizio Menichelli; Alessandra Scoccia; Aylin Hatice Yamac; Kadir Ugur Mert; Xacobe Flores Rios; Tomas Kovarnik; Michal Kidawa; Jose Moreu; Vincent Flavien; Enrico Fabris; Inigo Lozano Martinez-Luengas; Marco Boccalatte; Francisco Bosa Ojeda; Carlos Arellano-Serrano; Gianluca Caiazzo; Giuseppe Cirrincione; Hsien-Li Kao; Juan Sanchis Fores; Luigi Vignali; Helder Pereira; Santiago Ordonez; Alev Arat Ozkan; Bruno Scheller; Heidi Lehtola; Rui Teles; Christos Mantis; Ylitalo Antti; Joao Antonio Brum Silveira; Cesar Rodrigo Zoni; Ivan Bessonov; Giuseppe Uccello; George Kochiadakis; Dimitrios Alexopulos; Carlos E. Uribe; John Kanakakis; Benjamin Faurie; Gabriele Gabrielli; Alejandro Gutierrez Barrios; Juan Pablo Bachini; Alex Rocha; Frankie C. C. Tam; Alfredo Rodriguez; Antonia Anna Lukito; Veauthyelau Saint-Joy; Gustavo Pessah; Andrea Tuccillo; Alfonso Ielasi; Giuliana Cortese; Guido Parodi; Mohamed Abed Bouraghda; Marcia Moura; Elvin Kedhi; Pablo Lamelas; Harry Suryapranata; Matteo Nardin; Monica Verdoia

doi:10.3390/jcm12030896

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Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

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Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Giuseppe De Luca, Stephane Manzo-Silberman, Magdy Algowhary, Berat Uguz, Dinaldo C. Oliveira, Vladimir Ganyukov, Oliver Busljetik, Miha Cercek, Lisette Okkels, Poay Huan Loh, …

Journal of clinical medicine, Vol.12(3), p.896

01/23/2023

DOI: 10.3390/jcm12030896

PMCID: PMC9918240

PMID: 36769546

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Abstract

Background. Several reports have demonstrated the impact of the COVID-19 pandemic on the management and outcome of patients with ST-segment elevation myocardial infarction (STEMI). The aim of the current analysis is to investigate the potential gender difference in the effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI patients within the ISACS-STEMI COVID-19 Registry. Methods. This retrospective multicenter registry was performed in high-volume primary percutaneous coronary intervention (PPCI) centers on four continents and included STEMI patients undergoing PPCIs in March-June 2019 and 2020. Patients were divided according to gender. The main outcomes were the incidence and timing of the PPCI, (ischemia time >= 12 h and door-to-balloon >= 30 min) and in-hospital or 30-day mortality. Results. We included 16683 STEMI patients undergoing PPCIs in 109 centers. In 2020 during the pandemic, there was a significant reduction in PPCIs compared to 2019 (IRR 0.843 (95% CI: 0.825-0.861, p < 0.0001). We did not find a significant gender difference in the effects of the COVID-19 pandemic on the numbers of STEMI patients, which were similarly reduced from 2019 to 2020 in both groups, or in the mortality rates. Compared to prepandemia, 30-day mortality was significantly higher during the pandemic period among female (12.1% vs. 8.7%; adjusted HR [95% CI] = 1.66 [1.31-2.11], p < 0.001) but not male patients (5.8% vs. 6.7%; adjusted HR [95% CI] = 1.14 [0.96-1.34], p = 0.12). Conclusions. The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures similarly observed in both genders. Furthermore, we observed significantly increased in-hospital and 30-day mortality rates during the pandemic only among females. Trial registration number: NCT 04412655.

General & Internal Medicine

Life Sciences & Biomedicine

Medicine, General & Internal

Science & Technology

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Title: Subtitle: Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
Creators: Giuseppe De Luca - University of Messina
Stephane Manzo-Silberman - Assistance Publique – Hôpitaux de Paris
Magdy Algowhary - Assiut University
Berat Uguz - Bursa Technical University
Dinaldo C. Oliveira - Univ Fed Pernambuco, Ctr PROCAPE, Pronto Socorro Cardiol Prof Luis Tavares, BR-50670901 Recife, Brazil
Vladimir Ganyukov - Kemerovo State University
Oliver Busljetik - Saints Cyril and Methodius University of Skopje
Miha Cercek - Ljubljana University Medical Centre
Lisette Okkels - Odense University Hospital
Poay Huan Loh - National University Hospital
Lucian Calmac - Clinical Emergency Hospital Bucharest
Gerard Roura i Ferrer - Hosp Univ Bellvitge, Heart Dis Inst, Intervent Cardiol Unit, Barcelona 08016, Spain
Alexandre Quadros - Inst Cardiol Rio Grande do Sul, BR-90040371 Porto Alegre, Brazil
Marek Milewski - Medical University of Silesia
Fortunato Scotto di Uccio - Osped Mare, Div Cardiol, I-00156 Naples, Italy
Clemens von Birgelen - Medisch Spectrum Twente
Francesco Versaci - Ospedale Santa Maria Goretti
Jurrien Ten Berg - St Antonius Hosp, Div Cardiol, NL-3434 Nieuwegein, Netherlands
Gianni Casella - Ospedale Maggiore Carlo Alberto Pizzardi
Aaron Wong Sung Lung - National Heart Centre Singapore
Petr Kala - Masaryk University
Jose Luis Diez Gil - Hospital Universitari i Politècnic La Fe
Xavier Carrillo - Hospital Universitari Germans Trias i Pujol
Maurits Dirksen - Northwest Hospital
Victor Becerra - Hospital Clínico Universitario Virgen de la Victoria
Michael Kang-yin Lee - Queen Elizabeth Hospital
Dafsah Arifa Juzar - University of Indonesia
Rodrigo de Moura Joaquim - Inst Cardiol Santa Catarina Praia Comprida, BR-88103901 Sao Jose, Brazil
Roberto Paladino - Clin Villa Fiori, Div Cardiol, I-80011 Acerra, Italy
Davor Milicic - University Hospital Centre Zagreb
Periklis Davlouros - General University Hospital of Patras
Nikola Bakraceski - Ctr Cardiovasc Dis, Ohrid 6000, North Macedonia
Filippo Zilio - Ospedale Santa Chiara
Luca Donazzan - Ospedale di Bolzano
Adriaan Kraaijeveld - Utrecht University
Gennaro Galasso - Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
Lux Arpad - Maastricht University
Lucia Marinucci - Ospedali Riuniti Marche Nord
Vincenzo Guiducci - Azienda Sanitaria Unità Locale di Reggio Emilia
Maurizio Menichelli - Osped F Spaziani, Div Cardiol, I-03100 Frosinone, Italy
Alessandra Scoccia - Ospedale Sant'Anna
Aylin Hatice Yamac - Bezmiâlem Vakıf Üniversitesi
Kadir Ugur Mert - Eskişehir Osmangazi University
Xacobe Flores Rios - Complexo Hosp Univ La Coruna, La Coruna 15001, Spain
Tomas Kovarnik - General University Hospital in Prague
Michal Kidawa - Med Univ Lodz, Cent Hosp, PL-90008 Lodz, Poland
Jose Moreu - Complejo Hospitalario Universitario de Toledo
Vincent Flavien - Ctr Hosp Univ Lille, Div Cardiol, F-59000 Lille, France
Enrico Fabris - Azienda Ospedaliero Universitaria Ospedali Riuniti
Inigo Lozano Martinez-Luengas - Hospital de Cabueñes
Marco Boccalatte - Ospedale Santa Maria
Francisco Bosa Ojeda - Hospital Universitario de Canarias
Carlos Arellano-Serrano - Hospital Universitario Puerta de Hierro Majadahonda
Gianluca Caiazzo - Azienda Ospedaliera S.Giuseppe Moscati
Giuseppe Cirrincione - Azienda di Rilievo Nazionale ed Alta Specializzazione
Hsien-Li Kao - Natl Taiwan Univ Hosp, Dept Internal Med, Cardiol Div, Taipei 8865600, Taiwan
Juan Sanchis Fores - Hospital Clínico Universitario de Valencia
Luigi Vignali - Azienda Osped Sanit, Intervent Cardiol Unit, I-43121 Parma, Italy
Helder Pereira - Hospital Garcia de Orta
Santiago Ordonez - Instituto Cardiovascular de Buenos Aires
Alev Arat Ozkan - Istanbul University
Bruno Scheller - Saarland University
Heidi Lehtola - Oulu University Hospital
Rui Teles - Hospital de Santa Cruz
Christos Mantis - Agia Olga Hospital
Ylitalo Antti - Turku PET Centre
Joao Antonio Brum Silveira - Hosp Santo Antonio, Div Cardiol, P-4099001 Porto, Portugal
Cesar Rodrigo Zoni - Inst Cardiol Corrientes Juana F Cabral, Dept Teaching & Res, W3400CDS, Corrientes, Argentina
Ivan Bessonov - Russian Acad Sci, Tyumen Cardiol Res Ctr, Tomsk Natl Res Med Ctr, Tomsk 634000, Russia
Giuseppe Uccello - Alessandro Manzoni Hospital
George Kochiadakis - University Hospital of Heraklion
Dimitrios Alexopulos - University General Hospital Attikon
Carlos E. Uribe - Clínica CES
John Kanakakis - Alexandra Hospital
Benjamin Faurie - Groupe Hospitalier Mutualiste de Grenoble
Gabriele Gabrielli - Azienda Ospedaliero Universitaria Ospedali Riuniti
Alejandro Gutierrez Barrios - Hospital Universitario Puerta del Mar
Juan Pablo Bachini - Inst Cardiol Integral, Montevideo 11700, Uruguay
Alex Rocha - Instituto Nacional de Investigación Agropecuaria
Frankie C. C. Tam - Queen Mary Hospital
Alfredo Rodriguez - Sanatorio Otamendi y Miroli
Antonia Anna Lukito - Pelita Harapan University
Veauthyelau Saint-Joy - Ctr Hosp Antibes Juan Les Pins, F-06600 Antibes, France
Gustavo Pessah - Servicio Diabetología Hospital Córdoba
Andrea Tuccillo - Osped Mare, Div Cardiol, I-00156 Naples, Italy
Alfonso Ielasi - Istituto Clinico Sant'Ambrogio
Giuliana Cortese - University of Padua
Guido Parodi - Azienda Unità Sanitaria Locale Della Romagna
Mohamed Abed Bouraghda - Blida Univ Hosp, Div Cardiol, Blida 09000, Algeria
Marcia Moura - Inst Cardiol Rio Grande do Sul, BR-90040371 Porto Alegre, Brazil
Elvin Kedhi - Université Libre de Bruxelles
Pablo Lamelas - Instituto Cardiovascular de Buenos Aires
Harry Suryapranata - Radboud University Nijmegen
Matteo Nardin - Osped Riuniti, Dept Internal Med, I-25121 Brescia, Italy
Monica Verdoia - Ospedale degli Infermi
Resource Type: Journal article
Publication Details: Journal of clinical medicine, Vol.12(3), p.896
Publisher: Mdpi
DOI: 10.3390/jcm12030896
PMID: 36769546
PMCID: PMC9918240
ISSN: 2077-0383
eISSN: 2077-0383
Number of pages: 15
Language: English
Date published: 01/23/2023
Academic Unit: Electrical and Computer Engineering
Record Identifier: 9984627227602771

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