Gender-Specific Gene–Environment Interaction in Alcohol Dependence: The Impact of Daily Life Events and GABRA2

Brea L Perry; Bernice A Pescosolido; Kathleen Bucholz; Howard Edenberg; John Kramer; Samuel Kuperman; Marc Alan Schuckit; John I Nurnberger

doi:10.1007/s10519-013-9607-9

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Gender-Specific Gene–Environment Interaction in Alcohol Dependence: The Impact of Daily Life Events and GABRA2

Journal article

Peer reviewed

Gender-Specific Gene–Environment Interaction in Alcohol Dependence: The Impact of Daily Life Events and GABRA2

Brea L Perry, Bernice A Pescosolido, Kathleen Bucholz, Howard Edenberg, John Kramer, Samuel Kuperman, Marc Alan Schuckit and John I Nurnberger

Behavior genetics, Vol.43(5), pp.402-414

09/2013

DOI: 10.1007/s10519-013-9607-9

PMCID: PMC4441044

PMID: 23974430

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Abstract

Gender-moderated gene–environment interactions are rarely explored, raising concerns about inaccurate specification of etiological models and inferential errors. The current study examined the influence of gender, negative and positive daily life events, and GABRA2 genotype (SNP rs279871) on alcohol dependence, testing two- and three-way interactions between these variables using multilevel regression models fit to data from 2,281 White participants in the Collaborative Study on the Genetics of Alcoholism. Significant direct effects of variables of interest were identified, as well as gender-specific moderation of genetic risk on this SNP by social experiences. Higher levels of positive life events were protective for men with the high-risk genotype, but not among men with the low-risk genotype or women, regardless of genotype. Our findings support the disinhibition theory of alcohol dependence, suggesting that gender differences in social norms, constraints and opportunities, and behavioral undercontrol may explain men and women’s distinct patterns of association.

Genetics

Alcohol dependence

Gene–environment interaction

Daily hassles and uplifts

Gender

Details

Title: Subtitle: Gender-Specific Gene–Environment Interaction in Alcohol Dependence: The Impact of Daily Life Events and GABRA2
Creators: Brea L Perry - Department of Sociology, University of Kentucky, 1515 Patterson Office Tower, Lexington, KY 40506-0027, USA
Bernice A Pescosolido - Department of Sociology, Indiana University, Bloomington, IN, USA
Kathleen Bucholz - Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA
Howard Edenberg - Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
John Kramer - Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA, USA
Samuel Kuperman - Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA, USA
Marc Alan Schuckit - Department of Psychiatry, University of California, San Diego, CA, USA
John I Nurnberger - Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
Resource Type: Journal article
Publication Details: Behavior genetics, Vol.43(5), pp.402-414
DOI: 10.1007/s10519-013-9607-9
PMID: 23974430
PMCID: PMC4441044
NLM abbreviation: Behav Genet
ISSN: 0001-8244
eISSN: 1573-3297
Language: English
Date published: 09/2013
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984003477702771

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