Journal article
Gender differences in use of prescription narcotic medications among living kidney donors
Clinical transplantation, Vol.29(10), pp.927-937
10/01/2015
DOI: 10.1111/ctr.12599
PMCID: PMC4805522
PMID: 26227016
Abstract
Prescription narcotic use among living kidney donors is not well described. Using a unique database that integrates national registry identifiers for living kidney donors (1987-2007) in the United States with billing claims from a private health insurer (2000-2007), we identified pharmacy fills for prescription narcotic medications in periods 1-4 and >4yr post-donation and estimated relative likelihoods of post-donation narcotic use by Cox regression. We also compared narcotic fill rates and medication possession ratios (MPRs, defined as (days of medication supplied)/(days observed)), between donors and age- and sex-matched non-donors. Overall, rates of narcotic medication fills were 32.3 and 32.4 per 100 person-years in periods 1-4 and >4yr post-donation. After age and race adjustment, women were approximately twice as likely as men to fill a narcotic prescription in years 1-4 (adjusted hazard ratio, aHR, 2.28; 95% confidence interval, CI, 1.86-2.79) and >4yr (aHR 1.70; 95% CI 1.50-1.93). MPRs in donors were low (<2.5% days exposed), and lower than among age- and sex-matched non-donors. Prescription narcotic medication use is more common among women than men in the intermediate term after live kidney donation. Overall, total narcotic exposure is low, and lower than among non-donors from the general population.
Details
- Title: Subtitle
- Gender differences in use of prescription narcotic medications among living kidney donors
- Creators
- Krista L. Lentine - Saint Louis UniversityNgan N. Lam - University of AlbertaMark A. Schnitzler - Saint Louis UniversityAmit X. Garg - Western UniversityHuiling Xiao - Saint Louis UniversitySheila E. Leander - Saint Louis UniversityDaniel C. Brennan - Washington University in St. LouisSandra J. Taler - Mayo ClinicDavid Axelrod - Dartmouth–Hitchcock Medical CenterDorry L. Segev - Saint Louis University
- Resource Type
- Journal article
- Publication Details
- Clinical transplantation, Vol.29(10), pp.927-937
- DOI
- 10.1111/ctr.12599
- PMID
- 26227016
- PMCID
- PMC4805522
- NLM abbreviation
- Clin Transplant
- ISSN
- 0902-0063
- eISSN
- 1399-0012
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- Kidney Research Scientist Core Education and National Training Program (KRESCENT) New Investigator Award Dr. Adam Linton Chair in Kidney Health Analytics R01-DK096008; K24-DK101828 / National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K24DK101828 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 10/01/2015
- Academic Unit
- Surgery
- Record Identifier
- 9984322823502771
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