Gender-specific structural abnormalities in major depressive disorder revealed by fixel-based analysis

Matt Lyon; Thomas Welton; Adrina Varda; Jerome J. Maller; Kathryn Broadhouse; Mayuresh S. Korgaonkar; Stephen H. Koslow; Leanne M. Williams; Evian Gordon; A. John Rush; Stuart M. Grieve

doi:10.1016/j.nicl.2019.101668

Back

Gender-specific structural abnormalities in major depressive disorder revealed by fixel-based analysis

Journal article

Open access

Peer reviewed

Gender-specific structural abnormalities in major depressive disorder revealed by fixel-based analysis

Matt Lyon, Thomas Welton, Adrina Varda, Jerome J. Maller, Kathryn Broadhouse, Mayuresh S. Korgaonkar, Stephen H. Koslow, Leanne M. Williams, Evian Gordon, A. John Rush, …

NeuroImage clinical, Vol.21, pp.101668-101668

01/01/2019

DOI: 10.1016/j.nicl.2019.101668

PMCID: PMC6356005

PMID: 30690418

Files and links (1)

url

https://doi.org/10.1016/j.nicl.2019.101668View

Published (Version of record) Open Access

Abstract

Background: Major depressive disorder (MDD) is a chronic disease with a large global impact. There are currently no clinically useful predictors of treatment outcome, and the development of biomarkers to inform clinical treatment decisions is highly desirable. Methods: In this exploratory study we performed fixel-based analysis of diffusion MRI data from the International Study to Predict Optimized Treatment in Depression with the aim of identifying novel biomarkers at baseline that may relate to diagnosis and outcome to treatment with antidepressant medications. Analyses used MR data from individuals with MDD (n = 221) and healthy controls (n = 67). Results: We show focal, gender-specific differences in the anterior limb of the internal capsule (males) and bilaterally in the genu of the corpus callosum (females) associated with diagnosis. Lower fibre cross-section in the tapetum, the conduit between the right and left hippocampi, were also associated with a decreased probability of remission. Analysis of conventional fractional anisotropy showed scattered abnormalities in the corona radiata, cerebral peduncles and mid-brain which were much lower in total volume compared to fixel-based analysis. Conclusions: Fixel-based analysis appeared to identify different underlying abnormalities than conventional tensor-based metrics, with almost no overlap between significant regions. We show that MDD is associated with gender specific abnormalities in the genu of the corpus callosum (females) and in the anterior limb of the internal capsule (males), as well as gender-independent differences in the tapetum that predict remission. Diffusion MRI may play a key role in future guidance of clinical decision-making for MDD.

Life Sciences & Biomedicine

Neuroimaging

Neurosciences & Neurology

Science & Technology

Details

Title: Subtitle: Gender-specific structural abnormalities in major depressive disorder revealed by fixel-based analysis
Creators: Matt Lyon - The University of Sydney
Thomas Welton - The University of Sydney
Adrina Varda - The University of Notre Dame Australia
Jerome J. Maller - The Heart Research Institute
Kathryn Broadhouse - The Heart Research Institute
Mayuresh S. Korgaonkar - Westmead Institute for Medical Research
Stephen H. Koslow - University of Miami
Leanne M. Williams - VA Palo Alto Health Care System
Evian Gordon - The Heart Research Institute
A. John Rush - National University of Singapore
Stuart M. Grieve - Royal Prince Alfred Hospital
Resource Type: Journal article
Publication Details: NeuroImage clinical, Vol.21, pp.101668-101668
DOI: 10.1016/j.nicl.2019.101668
PMID: 30690418
PMCID: PMC6356005
NLM abbreviation: Neuroimage Clin
ISSN: 2213-1582
eISSN: 2213-1582
Publisher: Elsevier
Number of pages: 8
Grant note: Parker-Hughes Bequest Heart Research Institute; University of Sydney NCT00693849 / Brain Resource Ltd.
Language: English
Date published: 01/01/2019
Academic Unit: Radiology
Record Identifier: 9984848500702771

Metrics

4 Record Views

See more details