Journal article
Gene Conversion and Crossing Over Along the 405-kb Left Arm of Saccharomyces cerevisiae Chromosome VII
Genetics (Austin), Vol.168(1), pp.49-63
09/2004
DOI: 10.1534/genetics.104.027961
PMCID: PMC1448106
PMID: 15454526
Abstract
Gene conversions and crossing over were analyzed along 10 intervals in a 405-kb region comprising nearly all of the left arm of chromosome VII in
Saccharomyces cerevisiae
. Crossover interference was detected in all intervals as measured by a reduced number of nonparental ditypes. We have evaluated interference between crossovers in adjacent intervals by methods that retain the information contained in tetrads as opposed to single segregants. Interference was seen between intervals when the distance in the region adjacent to a crossover was <∼35 cM (90 kb). At the
met13
locus, which exhibits ∼9% gene conversions, those gene conversions accompanied by crossing over exerted interference in exchanges in an adjacent interval, whereas
met13
gene conversions without an accompanying exchange did not show interference. The pattern of exchanges along this chromosome arm can be represented by a counting model in which there are three nonexchange events between adjacent exchanges; however, maximum-likelihood analysis suggests that ∼8–12% of the crossovers on chromosome VII arise by a separate, noninterfering mechanism.
Details
- Title: Subtitle
- Gene Conversion and Crossing Over Along the 405-kb Left Arm of Saccharomyces cerevisiae Chromosome VII
- Creators
- Anna Malkova - Department of Biology and Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02454-9110 Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229 Department of Mathematics and Department of Biology, Indiana University, Bloomington, Indiana 47405Johanna Swanson - Department of Biology and Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02454-9110 Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229 Department of Mathematics and Department of Biology, Indiana University, Bloomington, Indiana 47405Miriam German - Department of Biology and Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02454-9110 Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229 Department of Mathematics and Department of Biology, Indiana University, Bloomington, Indiana 47405John H McCusker - Department of Biology and Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02454-9110 Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229 Department of Mathematics and Department of Biology, Indiana University, Bloomington, Indiana 47405Elizabeth A Housworth - Department of Biology and Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02454-9110 Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229 Department of Mathematics and Department of Biology, Indiana University, Bloomington, Indiana 47405Franklin W Stahl - Department of Biology and Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02454-9110 Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229 Department of Mathematics and Department of Biology, Indiana University, Bloomington, Indiana 47405James E Haber - Department of Biology and Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02454-9110 Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229 Department of Mathematics and Department of Biology, Indiana University, Bloomington, Indiana 47405
- Resource Type
- Journal article
- Publication Details
- Genetics (Austin), Vol.168(1), pp.49-63
- DOI
- 10.1534/genetics.104.027961
- PMID
- 15454526
- PMCID
- PMC1448106
- NLM abbreviation
- Genetics
- ISSN
- 0016-6731
- eISSN
- 1943-2631
- Publisher
- Genetics Society of America
- Language
- English
- Date published
- 09/2004
- Academic Unit
- Biology
- Record Identifier
- 9984217428502771
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