Gene Enrichment in an American-Indian Population - an Excess of Severe Combined Immunodeficiency Disease

Shirley Murphy; Gary Troup; Anthony Hayward; Eric J. Devor; Teresa Coons

doi:10.1016/s0140-6736(80)91833-4

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Gene Enrichment in an American-Indian Population - an Excess of Severe Combined Immunodeficiency Disease

Journal article

Peer reviewed

Gene Enrichment in an American-Indian Population - an Excess of Severe Combined Immunodeficiency Disease

Shirley Murphy, Gary Troup, Anthony Hayward, Eric J. Devor and Teresa Coons

Lancet, Vol.2(8193), pp.502-505

01/01/1980

DOI: 10.1016/s0140-6736(80)91833-4

PMID: 6105560

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Abstract

A subgroup of Athabascan Indians in Arizona and New Mexico was found to have an unusually high incidence of severe combined immunodeficiency, probably due to founder effect. Closed genetic pressures have limited their histocompatibility-antigen heterogeneity, enabling 3 patients to be grafted, 2 of them across HLA-B locus barriers.

Obstetrics and Gynecology

Details

Title: Subtitle: Gene Enrichment in an American-Indian Population - an Excess of Severe Combined Immunodeficiency Disease
Creators: Shirley Murphy
Gary Troup
Anthony Hayward
Eric J. Devor - University of Iowa
Teresa Coons
Resource Type: Journal article
Publication Details: Lancet, Vol.2(8193), pp.502-505
DOI: 10.1016/s0140-6736(80)91833-4
PMID: 6105560
ISSN: 0140-6736
Language: English
Date published: 01/01/1980
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9983557453702771

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