Journal article
Gene and environment interaction in familial suicidal behavior A single family with 4 committed suicides
Saudi medical journal, Vol.32(10), pp.1073-1077
10/01/2011
PMID: 22008930
Abstract
Family history of suicide is among the strongest predictors of suicide risk. From the context of gene by environment interactions, this manuscript presents a case study of the "M" family, which experienced 4 committed suicides within a short time period. Over the course of 5 years, the father and 3 sons committed suicide. Suicidal ideations developed in several other members of the family. The family's suicide risk appears to have stemmed from both environmental and genetic factors, and likely from an interactive effect between both. Environmental factors included low level of education, opium dependency among male family members, unemployment, and poverty, and limited access to mental health services. Genotype analyses of A218C polymorphism among surviving family members revealed that all individuals were associated with the gene variation (genotypes CC and AC) in tryptophan hydroxylase. The genetic by environmental interaction influence is discussed.
Details
- Title: Subtitle
- Gene and environment interaction in familial suicidal behavior A single family with 4 committed suicides
- Creators
- Habibolah Khazaie - Kermanshah Univ Med Sci, Sch Med, Sleep Res Ctr, Kermanshah, IranLeeba Rezaie - Kermanshah Univ Med Sci, Sch Med, Sleep Res Ctr, Kermanshah, IranReza Alibakhshi - Kermanshah Univ Med Sci, Sch Med, Dept Psychiat, Dept Biochem, Kermanshah, IranDavid C. Schwebel - University of Alabama
- Resource Type
- Journal article
- Publication Details
- Saudi medical journal, Vol.32(10), pp.1073-1077
- PMID
- 22008930
- NLM abbreviation
- Saudi Med J
- ISSN
- 0379-5284
- eISSN
- 1658-3175
- Publisher
- Saudi Med J
- Number of pages
- 5
- Language
- English
- Date published
- 10/01/2011
- Academic Unit
- Research Administration
- Record Identifier
- 9984949478202771
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