Journal article
Gene dosage of the amyloid β precursor protein in Alzheimer's disease
Science (American Association for the Advancement of Science), Vol.238(4827), pp.669-671
1987
DOI: 10.1126/science.2960019
PMID: 2960019
Abstract
The progressive deposition in the human brain of amyloid filaments composed of the amyloid beta protein is a principal feature of Alzheimer's disease (AD). Densitometric analysis of Southern blots probed with a complementary DNA for the amyloid protein has been carried out to determine the relative dosage of this gene in genomic DNA of 14 patients with AD, 12 aged normal subjects, and 10 patients with trisomy 21 (Down syndrome). Whereas patients in the last group showed the expected 1.5-fold increase in dosage of this gene, none of the patients with AD had a gene dosage higher than that of the normal controls. These results do not support the hypothesis that the genetic defect in AD involves duplication of a segment of chromosome 21 containing the amyloid gene. Alternative mechanisms for the brain-specific increase in amyloid protein deposition in AD should be considered.
Details
- Title: Subtitle
- Gene dosage of the amyloid β precursor protein in Alzheimer's disease
- Creators
- M. B PODLISNY - Harvard medical school, dep. neurology, Boston MA 02115, United StatesG LEE - Harvard medical school, dep. neurology, Boston MA 02115, United StatesD. J SELKOE - Harvard medical school, dep. neurology, Boston MA 02115, United States
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.238(4827), pp.669-671
- Publisher
- American Association for the Advancement of Science; Washington, DC
- DOI
- 10.1126/science.2960019
- PMID
- 2960019
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 1987
- Academic Unit
- Iowa Neuroscience Institute; Immunology; Internal Medicine
- Record Identifier
- 9984065398302771
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