Journal article
Gene-environment interaction in molar-incisor hypomineralization
PloS one, Vol.16(1), pp.e0241898-e0241898
2021
DOI: 10.1371/journal.pone.0241898
PMCID: PMC7787379
PMID: 33406080
Abstract
Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur when there are disturbances during the mineralization or maturation stage of amelogenesis. Both genetic and environmental factors have been suggested to play roles in MIH's development, but no conclusive risk factors have shown the source of the disease. During head and neck development, the interferon regulatory factor 6 (IRF6) gene is involved in the structure formation of the oral and maxillofacial regions, and the transforming growth factor alpha (TGFA) is an essential cell regulator, acting during proliferation, differentiation, migration and apoptosis. In this present study, it was hypothesized that these genes interact and contribute to predisposition of MIH. Environmental factors affecting children that were 3 years of age or older were also hypothesized to play a role in the disease etiology. Those factors included respiratory issues, malnutrition, food intolerance, infection of any sort and medication intake. A total of 1,065 salivary samples from four different cohorts were obtained, and DNA was extracted from each sample and genotyped for nine different single nucleotide polymorphisms. Association tests and logistic regression implemented in PLINK were used for analyses. A potential interaction between TGFA rs930655 with all markers tested in the cohort from Turkey was identified. These interactions were not identified in the remaining cohorts. Associations (p<0.05) between the use of medication after three years of age and MIH were also found, suggesting that conditions acquired at the age children start to socialize might contribute to the development of MIH.
Details
- Title: Subtitle
- Gene-environment interaction in molar-incisor hypomineralization
- Creators
- Mariana Bezamat - University of PittsburghJuliana F Souza - Universidade Federal do ParanáFernanda M F Silva - Universidade Federal do Rio de JaneiroEmilly G Corrêa - Pontifícia Universidade Católica do ParanáAluhe L Fatturi - Universidade Federal do ParanáJoão A Brancher - Universidade PositivoFlávia M Carvalho - Fundação Oswaldo CruzTayla Cavallari - Pontifícia Universidade Católica do ParanáLaís Bertolazo - Pontifícia Universidade Católica do ParanáCleber Machado-Souza - Centro Universitário de João PessoaMine Koruyucu - Istanbul UniversityMerve Bayram - Istanbul Medipol UniversityAndrea Racic - University of PittsburghBenjamin M Harrison - University of PittsburghYan Y Sweat - University of IowaAriadne Letra - Department of Diagnostic and Biomedical Sciences, and Center for Craniofacial Research, UTHealth School of Dentistry at Houston, Houston, Texas, United States of America.Deborah Studen-Pavlovich - University of PittsburghFigen Seymen - Istanbul UniversityBrad Amendt - University of IowaRenata I Werneck - Pontifícia Universidade Católica do ParanáMarcelo C Costa - Universidade Federal do Rio de JaneiroAdriana Modesto - University of PittsburghAlexandre R Vieira - University of Pittsburgh
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.16(1), pp.e0241898-e0241898
- DOI
- 10.1371/journal.pone.0241898
- PMID
- 33406080
- PMCID
- PMC7787379
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Language
- English
- Date published
- 2021
- Academic Unit
- Orthodontics; Anatomy and Cell Biology; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984284451702771
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