Gene expression analysis of human otosclerotic stapedial footplates

Megan Ealy; Wenjie Chen; Gi-Yung Ryu; Jae-Geun Yoon; D. Bradley Welling; Marlan Hansen; Anup Madan; Richard J.H Smith

doi:10.1016/j.heares.2008.03.001

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Gene expression analysis of human otosclerotic stapedial footplates

Journal article

Open access

Peer reviewed

Gene expression analysis of human otosclerotic stapedial footplates

Megan Ealy, Wenjie Chen, Gi-Yung Ryu, Jae-Geun Yoon, D. Bradley Welling, Marlan Hansen, Anup Madan and Richard J.H Smith

Hearing research, Vol.240(1), pp.80-86

2008

DOI: 10.1016/j.heares.2008.03.001

PMCID: PMC2442649

PMID: 18430532

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Abstract

Otosclerosis is a complex disease that results in a common form of conductive hearing loss due to impaired mobility of the stapes. Stapedial motion becomes compromised secondary to invasion of otosclerotic foci into the stapedio-vestibular joint. Although environmental factors and genetic causes have been implicated in this process, the pathogenesis of otosclerosis remains poorly understood. To identify molecular contributors to otosclerosis we completed a microarray study of otosclerotic stapedial footplates. Stapes footplate samples from otosclerosis and control patients were used in the analysis. One-hundred-and-ten genes were found to be differentially expressed in otosclerosis samples. Ontological analysis of differentially expressed genes in otosclerosis provides evidence for the involvement of a number of pathways in the disease process that include interleukin signaling, inflammation and signal transduction, suggesting that aberrant regulation of these pathways leads to abnormal bone remodeling. Functional analyses of genes from this study will enhance our understanding of the pathogenesis of this disease.

Stapes

Microarray

Gene expression

Otosclerosis

Details

Title: Subtitle: Gene expression analysis of human otosclerotic stapedial footplates
Creators: Megan Ealy - Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, Pediatrics and Internal Medicine, Division of Nephrology, 200 Hawkins Drive – 21151 PFP, University of Iowa, Iowa City, IA, USA
Wenjie Chen - Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, Pediatrics and Internal Medicine, Division of Nephrology, 200 Hawkins Drive – 21151 PFP, University of Iowa, Iowa City, IA, USA
Gi-Yung Ryu - Neurogenomic Research Laboratory, Department of Neurosurgery, University of Iowa, Iowa City, IA, USA
Jae-Geun Yoon - Neurogenomic Research Laboratory, Department of Neurosurgery, University of Iowa, Iowa City, IA, USA
D. Bradley Welling - Department of Otolaryngology-Head and Neck Surgery, Ohio State University, Columbus, OH, USA
Marlan Hansen - Department of Otolaryngology, University of Iowa, Iowa City, IA, USA
Anup Madan - Neurogenomic Research Laboratory, Department of Neurosurgery, University of Iowa, Iowa City, IA, USA
Richard J.H Smith - Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, Pediatrics and Internal Medicine, Division of Nephrology, 200 Hawkins Drive – 21151 PFP, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Hearing research, Vol.240(1), pp.80-86
DOI: 10.1016/j.heares.2008.03.001
PMID: 18430532
PMCID: PMC2442649
NLM abbreviation: Hear Res
ISSN: 0378-5955
eISSN: 1878-5891
Publisher: Elsevier B.V
Language: English
Date published: 2008
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; ICTS - Biomedical Informatics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology; Internal Medicine
Record Identifier: 9984007183302771

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