Journal article
Gene regulation by chromatin structure: paradigms established in Drosophila melanogaster
Annual review of entomology, Vol.52, pp.171-192
2007
DOI: 10.1146/annurev.ento.51.110104.151007
PMID: 16881818
Abstract
Studies in Drosophila melanogaster have revealed paradigms for regulating gene expression through chromatin structure, including mechanisms of gene activation and silencing. Regulation occurs at the level of individual genes, chromosomal domains, and entire chromosomes. The chromatin state is dynamic, allowing for changes in gene expression in response to cellular signals and/or environmental cues. Changes in chromatin result from the action of ATP-dependent chromatin-remodeling complexes, reversible epigenetic histone modifications, and the incorporation of histone variants. Many of the chromatin-based transcriptional regulatory mechanisms discovered in D. melanogaster are evolutionarily conserved and therefore serve as a foundation for studies in other organisms.
Details
- Title: Subtitle
- Gene regulation by chromatin structure: paradigms established in Drosophila melanogaster
- Creators
- Sandra R Schulze - Department of Biology, Western Washington University, Bellingham, Washington 98225, USA. Sandra.Schulze@wwu.eduLori L Wallrath
- Resource Type
- Journal article
- Publication Details
- Annual review of entomology, Vol.52, pp.171-192
- Publisher
- United States
- DOI
- 10.1146/annurev.ento.51.110104.151007
- PMID
- 16881818
- ISSN
- 0066-4170
- eISSN
- 1545-4487
- Grant note
- GM61513 / NIGMS NIH HHS
- Language
- English
- Date published
- 2007
- Academic Unit
- Biochemistry and Molecular Biology; University College Courses
- Record Identifier
- 9984024543802771
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