Journal article
Gene therapy for cerebral vascular disease: update 2003
British journal of pharmacology, Vol.139(1), pp.1-9
05/2003
DOI: 10.1038/sj.bjp.0705217
PMCID: PMC1573819
PMID: 12746217
Abstract
Gene therapy is a promising strategy for cerebrovascular diseases. Several genes that encode vasoactive products have been transferred via cerebrospinal fluid for the prevention of vasospasm after subarachnoid hemorrhage. Transfer of neuroprotective genes, including targeting of proinflammatory mediators, is a current strategy of gene therapy for ischemic stroke. Stimulation of growth of collateral vessels, stabilization of atherosclerotic plaques, inhibition of thrombosis, and prevention of restenosis are important objectives of gene therapy for coronary and limb arteries, but application of these approaches to carotid and intracranial arteries has received little attention. Several fundamental advances, including development of safer vectors, are needed before gene therapy achieves an important role in the treatment of cerebrovascular disease and stroke.
Details
- Title: Subtitle
- Gene therapy for cerebral vascular disease: update 2003
- Creators
- Kazunori Toyoda - Department of Cerebrovascular Disease and Clinical Research Institute, National Kyushu Medical Center, Fukuoka 810-8563, JapanYi Chu - Departments of Internal Medicine and Pharmacology, and Cardiovascular Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, IA, U.S.ADonald D Heistad - Veterans Affairs Medical Center, Iowa City, IA 52242, U.S.A
- Resource Type
- Journal article
- Publication Details
- British journal of pharmacology, Vol.139(1), pp.1-9
- DOI
- 10.1038/sj.bjp.0705217
- PMID
- 12746217
- PMCID
- PMC1573819
- NLM abbreviation
- Br J Pharmacol
- ISSN
- 0007-1188
- eISSN
- 1476-5381
- Language
- English
- Date published
- 05/2003
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040319802771
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